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1,089 results
  • Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile. [Journal Article]
    J Sex Med 2019; 16(6):763-766Larish AM, Dickson RR, … Green IC
  • CONCLUSIONS: Serum plasma concentrations of vaginally administered diazepam are low; however the half-life is prolonged.Vaginal administration of diazepam results in lower peak serum plasma concentration, longer time to peak concentration, and lower bioavailability than standard oral use. Providers should be aware that with diazepam's long half-life, accumulating levels would occur with chronic daily doses, and steady-state levels would not be reached for up to 1 week. This profile would favor intermittent use to allow participation in physical therapy and intimacy. Larish AM, Dickson RR, Kudgus RA, et al. Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile. J Sex Med 2019;16;763-766.
  • StatPearls: Prescription of Controlled Substances: Benefits and Risks [BOOK]
    StatPearls Publishing: Treasure Island (FL) Preuss Charles V. CV University of South Florida Kalava Arun A University of South Florida King Kevin C. KC Geisinger Wyoming Valley Medical Center BOOK
  • One of the single most difficult challenges for any prescriber is to distinguish between the legitimate prescription of controlled substances versus the prescription potentially used for illegitimate purposes. To discern the difference prescribers need to understand the signs, symptoms, and treatment of acute and chronic pain as well as the signs and symptoms of patients using controlled substanc…
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