- Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. [Journal Article]
- BOBMJ Open 2019 Jun 22; 9(6):e025995
- CONCLUSIONS: Our review of tertiary and neurosyphilis cases found that early and late neurosyphilis cases continue to occur in the context of cycling syphilis outbreaks. CV syphilis cases were extremely rare. Ongoing identification of new cases of syphilis and clinical evaluation of cases for complications continues to be important in the context of global resurgence of syphilis.
- StatPearls: Neurosyphilis [BOOK]
- BOOKStatPearls Publishing: Treasure Island (FL)
- Syphilis is an infectious disease caused by the spirochete bacteria Treponema pallidum subspecies pallidum (T. pallidum). It has been deemed the "great imitator" due to the multitude of symptoms it p…
Syphilis is an infectious disease caused by the spirochete bacteria Treponema pallidum subspecies pallidum (T. pallidum). It has been deemed the "great imitator" due to the multitude of symptoms it produces. The diagnosis becomes further muddled by periods of active disease and latency. The term neurosyphilis refers to an infection involving the central nervous system (CNS) and unlike primary, secondary and tertiary syphilis, can occur at any time after infection. Studies on rabbits have shown that within hours of initial infection, treponemes may be present in the cerebral spinal fluid (CSF). Additionally, the belief is that bacterial neuroinvasion occurs in all patients and it is a failure of clearance which results in the condition. Five types of neurosyphilis exist which can be classified by either the early forms consisting of asymptomatic, meningeal, and meningovascular or the late forms of general paresis and tabes dorsalis. The latter generally occurs years or decades after initial inoculation.
- An isotopic case study of individuals with syphilis from the pathological-anatomical reference collection of the national museum in Prague (Czech Republic, 19th century A.D.). [Journal Article]
- IJInt J Paleopathol 2019; 25:46-55
- CONCLUSIONS: Either diets prescribed by physicians to syphilitic patients or nutritional stress caused by cyclic appetite disturbance due to the disease itself or the administered medical treatment appeared to be possible explanations of the observed isotopic pattern. Overall, the response of the two isotopic proxies could argue for relatively limited nutritional restrictions.This is the first study examining bone collagen isotopic response to syphilis based on clinically documented human skeletal materials.The sample sizes are relatively small and cautiousness must be taken regarding the interpretations of the data.
- Many Different Patterns under a Common Flag: Aortic Pathology in HIV-A Review of Case Reports in Literature. [Review]
- AVAnn Vasc Surg 2019 Apr 30
- CONCLUSIONS: Aortic pathology may occur in patients with HIV. The entanglement of different patterns of pathological involvement of the aortic wall, secondary to immune dysregulation, infectious process, or atherosclerotic damage that may co-occur in one single case, results in a very challenging management of the condition. Because of the increased life expectancy of patients and immigration from regions with both high HIV and coinfection prevalence, the incidence of aortic pathology could increase in the upcoming years, suggesting the urgent need for further studies to optimize management in these very complex cases.
- Aortic Thrombus in a Case of Tertiary Syphilis. [Journal Article]
- JEJ Emerg Med 2019; 56(5):564-565
- Syphilis. [Journal Article]
- EIEnferm Infecc Microbiol Clin 2019 Jun - Jul; 37(6):398-404
- Syphilis is an infectious disease caused by the spirochaete Treponema pallidum subsp. pallidum which is transmitted by sexual contact or vertical transmission during pregnancy. The incidence of syphi…
Syphilis is an infectious disease caused by the spirochaete Treponema pallidum subsp. pallidum which is transmitted by sexual contact or vertical transmission during pregnancy. The incidence of syphilis has increased in the last years, mainly among men who have sex with men. Without treatment, the disease develops into different clinical stages, being able to present cardiovascular or irreversible neurological complications after a number of years. The disease is classified as early syphilis - primary, secondary and early latent syphilis (less than 12 months) - which is contagious, and as late syphilis - late latent and tertiary syphilis- which is rarely contagious. Diagnosis and management are often a challenge because of its diversity of manifestations and the difficulty of interpretation of serological tests. The treatment of syphilis is based on penicillin or doxycycline in allergic patients. Treatment failure because of resistance has been described with azithromycin. The follow up with a serological test is recommended in all patients with syphilis in order to ascertain cure after the treatment and to diagnose possible reinfections.
- Gummatous Syphilis Mimicking Malignant Bone Tumor on FDG PET/CT. [Case Reports]
- CNClin Nucl Med 2019; 44(4):313-316
- A 47-year-old woman suffered worsening pain in the waist and numbness in the right thigh for 1 month. MRI was performed to determine the cause, which detected an osteolytic lesion in the T12 vertebra…
A 47-year-old woman suffered worsening pain in the waist and numbness in the right thigh for 1 month. MRI was performed to determine the cause, which detected an osteolytic lesion in the T12 vertebral body, suggestive of possible bone metastasis. FDG PET/CT scan was undertaken to detect the primary tumor, which only showed the same isolated lesion in the T12 without any other abnormal hypermetabolic lesion. The pathology following vertebrectomy revealed granulomatous infection. The diagnosis of osseous syphilis was eventually made following a subsequent positive Treponema pallidum serological test.
- An Unusual Case of Tertiary Syphilis Behaving Like Tongue Squamous Cell Carcinoma. [Journal Article]
- JIJ Investig Med High Impact Case Rep 2018 Jan-Dec; 6:2324709618820355
- Syphilis may present with a myriad of oral manifestations in the primary, secondary, and tertiary stages, and may be confused with malignancy. Despite a rise in the incidence of syphilis, tertiary sy…
Syphilis may present with a myriad of oral manifestations in the primary, secondary, and tertiary stages, and may be confused with malignancy. Despite a rise in the incidence of syphilis, tertiary syphilis is exceedingly rare. Tertiary syphilis gummas usually affect the hard palate, while tongue involvement is very rare. A 55-year-old male with extensive smoking and alcohol use was referred for malignancy evaluation with an ulcerative mass creating a tongue cleft, and a positron emission tomography scan suggestive for malignancy. Biopsy results demonstrated no carcinoma but histology demonstrated granulomatous inflammation. Further laboratory results demonstrated elevated rapid plasma reagin titers with Treponema pallidum immunoglobulin G antibodies present. The patient was diagnosed with tertiary syphilis, received appropriate antibiotic therapy, and had healing of the tongue with a persistent cleft. Syphilis may mimic many disease processes. As such, it is important to include this disease in the differential of an unusual tongue lesion. An oral lesion may be the first sign of infection.
- Tubero-Ulcero-Serpiginous Syphilid (A52.7) in Tertiary Syphilis. [Journal Article]
- DADtsch Arztebl Int 2018 11 02; 115(44):750
New Search Next
- Modelling the risk of transfusion-transmitted syphilis: a reconsideration of blood donation testing strategies. [Journal Article]
- VSVox Sang 2019; 114(2):107-116
- CONCLUSIONS: Universal testing is not required to maintain the risk of TTS within tolerable limits and is estimated to greatly exceed acceptable ICERs for blood safety interventions. However, despite a strong economic and risk-based rationale, given the epidemiology of syphilis in Australia is changing, feedback from critical stakeholders is not currently supportive of reducing testing.