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(therapeutic cloning)
11,525 results
  • Protective antigen domain 4 of Bacillus anthracis as a candidate for use as vaccine for anthrax. [Journal Article]
    Ann Agric Environ Med 2019; 26(3):392-395Żakowska D, Graniak G, … Niemcewicz M
  • Existing research for using the protective antigen (PA) of Bacillus anthracis as a vaccine component shows that protection against anthrax may be obtained using fragments of this protein. The aim of the research is to check whether the selected protein fragment of the protective antigen (domain 4) encoded by an appropriate nucleotide sequence of gene pag of B. anthracis, was expressed in the bact…
  • Rock-paper-scissors: Engineered population dynamics increase genetic stability. [Journal Article]
    Science 2019; 365(6457):1045-1049Liao MJ, Din MO, … Hasty J
  • Advances in synthetic biology have led to an arsenal of proof-of-principle bacterial circuits that can be leveraged for applications ranging from therapeutics to bioproduction. A unifying challenge for most applications is the presence of selective pressures that lead to high mutation rates for engineered bacteria. A common strategy is to develop cloning technologies aimed at increasing the fixat…
  • Unlimited expansion of intestinal stem cells from a wide range of ages. [Journal Article]
    Integr Mol Med 2019; 6(4)Duleba M, Mahalingam R, … Xian W
  • The recent technical advance in cloning and culturing ground-state intestinal stem cells (ISC) provides us an opportunity of accurate assessment of age-related impact on the function of highly proliferative intestinal stem cells. Our ability of indefinitely and robustly expanding single-stem-cell derived pedigrees in vitro allows us to study intestinal stem cells at the clonal level. Interestingl…
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