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(thienopyridine)
1,105 results
  • Influence of CYP450 Enzymes, CES1, PON1, ABCB1, and P2RY12 Polymorphisms on Clopidogrel Response in Patients Subjected to a Percutaneous Neurointervention. [Journal Article]
  • CTClin Ther 2019; 41(6):1199-1212.e2
  • Saiz-Rodríguez M, Belmonte C, … Abad-Santos F
  • CONCLUSIONS: Therapeutic guidelines recommend that CYP2C19 intermediate and poor metabolizers with acute coronary syndromes undergoing percutaneous coronary intervention receive an alternative antiplatelet therapy; however, genotype-guided therapy is not a standard recommendation for neurovascular conditions. This is the first study to carry out a joint analysis of CYP2C19 and other genes involved in clopidogrel treatment in patients receiving percutaneous neurointervention. Our findings support routine genotyping in clopidogrel-treated patients. Moreover, we encourage considering an alternative antiplatelet therapy in CYP2C19 intermediate, poor and ultrarapid metabolizers. Additionally, ABCB1 polymorphisms could be considered for a better pharmacogenetic approach.
  • Pharmacology of P2Y receptors. [Review]
  • BRBrain Res Bull 2019 Mar 25
  • von Kügelgen I
  • P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11) and…
  • Antithrombotics in stable peripheral artery disease. [Review]
  • VMVasc Med 2019; 24(2):132-140
  • Kaplovitch E, Rannelli L, Anand SS
  • Patients with peripheral artery disease (PAD) are at high risk for ischemic cardiovascular complications. While single antiplatelet therapy (SAPT), predominantly aspirin, has long been the standard a…
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