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Did you mean: (thrombolytic)?
174,510 results
  • Engineered Micro- and Nanoparticles for Fibrinolysis. [Review]
    J Thromb Haemost 2019Disharoon D, Marr DWM, Neeves KB
  • Fibrinolytic agents including plasmin and plasminogen activators improve outcomes in acute ischemic stroke and thrombosis by recanalizing occluded vessels. In the decades since their introduction into clinical practice, several limitations of have been identified both in terms of efficacy and bleeding risk associated with these agents. Engineered nano- and microparticles address some of these lim…
  • Thrombolytics for Acute Myocardial Infarction in a Prehospital Setting: A Review of Comparative Safety, and Guidelines [BOOK]
    Canadian Agency for Drugs and Technologies in Health: Ottawa (ON) Marchand Dave K. DK Farrah Kelly K BOOK
  • Myocardial infarction is an acute coronary syndrome in which the heart muscle undergoes injury due to ischemia (lack of blood supply).1 About 63,200 adult Canadians had a first myocardial infarction in the 2012–2013 fiscal year.2 Older Canadians are disproportionately affected, causing major morbidity and mortality, with an estimated 630,203 years of life lost3 and 30,894 years lived with disabil…
  • Plasminflammation-An Emerging Pathway to Bradykinin Production. [Review]
    Front Immunol 2019; 10:2046Maas C
  • Plasminogen activation is essential for fibrinolysis-the breakdown of fibrin polymers in blood clots. Besides this important function, plasminogen activation participates in a wide variety of inflammatory conditions. One of these conditions is hereditary angioedema (HAE), a rare disease with characteristic attacks of aggressive tissue swelling due to unregulated production and activity of the inf…
  • [Drug Repositioning for Alzheimer's Disease]. [Journal Article]
    Brain Nerve 2019; 71(9):961-970Ihara M, Saito S
  • To date, all clinical trials of disease-modifying drugs for Alzheimer's disease (AD) have been unsuccessful, making investments into AD drug development very risky despite the high unmet need. Drug repositioning or repurposing approaches are relatively less expensive and more promising compared to novel drug development in AD. About 40% of clinical trials for AD currently in progress across the w…
  • Prosthetic Mitral Valve Obstruction with Left Atrial Appendage Thrombus: A Therapeutic Dilemma. [Case Reports]
    Cureus 2019; 11(6):e5011Ravi V, Chandran A, … Yadav N
  • Valvular obstruction is a rare but life-threatening complication of mechanical prosthetic valves that raises significant challenges in management. We describe a unique case of mechanical mitral valve obstruction with co-existing left atrial appendage (LAA) thrombus. A 48-year-old man with a past medical history of atrial fibrillation and mechanical mitral valve replacement 18 months prior, presen…
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