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21,413 results
  • Cre-loxP Reporter Mouse Reveals Stochastic Activity of the Foxp3 Promoter. [Journal Article]
    Front Immunol 2019; 10:2228Bittner-Eddy PD, Fischer LA, Costalonga M
  • Mouse models that combine specific loxP-flanked gene sequences with Cre recombinase expressed from cell-regulated promoters have become important tools to investigate gene function. Critically however, expression of Cre recombinase may not always be restricted to the target cell or tissue of interest due to promiscuous activity of the driving promoter. Expression of Cre recombinase and, by extens…
  • High-Fat Diet from Weaning until Early Adulthood Impairs T Cell Development in the Thymus. [Journal Article]
    Lipids 2019Li H, Wetchapinant C, … Wu K
  • The growing prevalence of childhood obesity has become a serious health problem over the past few decades. Although the immune system is greatly affected by childhood obesity, whether obesity influences the T cell development in the thymus is poorly understood. In this study, we used a high-fat diet (HFD)-induced obesity mice model to study the influence of HFD from weaning on the thymus. C57BL/6…
  • Regulatory T Cell Development in the Thymus. [Review]
    J Immunol 2019; 203(8):2031-2041Owen DL, Sjaastad LE, Farrar MA
  • Development of a comprehensive regulatory T (Treg) cell compartment in the thymus is required to maintain immune homeostasis and prevent autoimmunity. In this study, we review cellular and molecular determinants of Treg cell development in the thymus. We focus on the evidence for a self-antigen-focused Treg cell repertoire as well as the APCs responsible for presenting self-antigens to developing…
  • Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules. [Journal Article]
    Proc Natl Acad Sci U S A 2019Krovi SH, Kappler JW, … Gapin L
  • The repertoire of αβ T cell antigen receptors (TCRs) on mature T cells is selected in the thymus where it is rendered both self-tolerant and restricted to the recognition of major histocompatibility complex molecules presenting peptide antigens (pMHC). It remains unclear whether germline TCR sequences exhibit an inherent bias to interact with pMHC prior to selection. Here, we isolated TCR librari…
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