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4,409 results
  • Immune and Inflammatory Cells in Thyroid Cancer Microenvironment. [Review]
    Int J Mol Sci 2019; 20(18)Ferrari SM, Fallahi P, … Antonelli A
  • A hallmark of cancer is the ability of tumor cells to avoid immune destruction. Activated immune cells in tumor microenvironment (TME) secrete proinflammatory cytokines and chemokines which foster the proliferation of tumor cells. Specific antigens expressed by cancer cells are recognized by the main actors of immune response that are involved in their elimination (immunosurveillance). By the rec…
  • Long Non-coding RNA Expression in Anaplastic Thyroid Carcinomas. [Journal Article]
    Endocr Pathol 2019Wang Y, Hardin H, … Lloyd RV
  • Long non-coding RNAs (lncRNAs) participate in transcription and in epigenetic or post-transcriptional regulation of gene expression. They also have roles in epithelial to mesenchymal transition and in carcinogenesis. Because lncRNAs may also have a role in thyroid cancer progression, we examined a group of thyroid tumors which included papillary thyroid carcinomas and anaplastic thyroid carcinoma…
  • Slc:Wistar/ST rats develop unilateral thyroid dysgenesis: A novel animal model of thyroid hemiagenesis. [Journal Article]
    PLoS One 2019; 14(8):e0221939Nakamura T, Ichii O, … Nagasaki KI
  • Developmental anomalies of the thyroid gland lead to congenital malformations such as thyroglossal duct cysts and thyroid dysgenesis. However, the pathogenesis of thyroid dysgenesis remains unclear due to the lack of suitable animal models. This study demonstrated that Slc:Wistar/ST rats frequently developed unilateral thyroid dysgenesis, including hemiagenesis, characterized by the absence of on…
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