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269 results
  • Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo. [Review]
    J Bone Oncol 2018; 12:19-22Zangari M, Yoo H, … Suva LJ
  • The 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the ef…
  • Thymic PTH Increases After Thyroparathyroidectomy in C57BL/KaLwRij Mice. [Journal Article]
    Endocrinology 2018; 159(4):1561-1569Zangari M, Yoo H, … Yoon D
  • We previously reported a substantial correlation between serum parathyroid hormone (PTH) levels and the myeloma response to proteasome inhibition that suggests a crucial role for the PTH receptor 1 system in the control of myeloma tumor growth. While investigating the role of PTH in the antimyeloma effect, we observed the recovery of serum PTH levels after thyroparathyroidectomy (TPTX). Although …
  • Hypercalcemic crisis due to primary hyperparathyroidism occurring concomitantly with Graves' disease. [Case Reports]
    Intern Med 2015; 54(7):813-8Yokomoto M, Minamoto M, … Kondo S
  • We herein describe a case of hypercalcemic crisis in a 52-year-old Japanese woman. She suffered from thirst and fatigue for one month. Her serum calcium (a) levels were 19.0 mg/dL, and she was diagnosed with hypercalcemic crisis. Circulating levels of parathyroid and thyroid hormones were elevated. She was diagnosed with primary hyperparathyroidism accompanied by Graves' disease. Thyroparathyroid…
  • Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis. [Journal Article]
    J Am Soc Nephrol 2014; 25(4):761-72Nomura K, Tatsumi S, … Miyamoto K
  • Marked hypophosphatemia is common after major hepatic resection, but the pathophysiologic mechanism remains unknown. We used a partial hepatectomy (PH) rat model to investigate the molecular basis of hypophosphatemia. PH rats exhibited hypophosphatemia and hyperphosphaturia. In renal and intestinal brush-border membrane vesicles isolated from PH rats, Na(+)-dependent phosphate (Pi) uptake decreas…
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