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57,319 results
  • Autoimmune Polyglandular Syndrome Type II Presenting as an Endocrine Emergency: A Case Report. [Case Reports]
    Oman Med J 2013; 28(3):e048Sonthalia N, Ray S, … Maitra S
  • We describe the case of a 30-year-old male, a known patient of type 1 diabetes mellitus (DM) on insulin therapy, seeking medical attention for recent onset repeated attacks of hypoglycemia associated with generalized weakness and darkening of skin. Further evaluation and screening revealed autoimmune adrenal failure together with presence of Hashimoto's thyroiditis. The patient was diagnosed as a…
  • Aging is associated with low thyroid state and organ specific sensitivity to thyroxine. [Journal Article]
    Thyroid 2019Rakov H, De Angelis M, … Fuehrer D
  • CONCLUSIONS: We suggest that reduced activity of the aged thyroid is responsible for the systemic low TH state in old mice. Furthermore, divergent TH metabolism and tissue response in liver and heart occur after T4 treatment in an aged organism. These rodent data are in agreement with a much narrower window for T4 substitution in the elderly patients to avoid overtreatment.
  • Thyroid Hormone Distributor Proteins During Development in Vertebrates. [Review]
    Front Endocrinol (Lausanne) 2019; 10:506Rabah SA, Gowan IL, … Richardson SJ
  • Thyroid hormones (THs) are ancient hormones that not only influence the growth, development and metabolism of vertebrates but also affect the metabolism of (at least some) bacteria. Synthesized in the thyroid gland (or follicular cells in fish not having a discrete thyroid gland), THs can act on target cells by genomic or non-genomic mechanisms. Either way, THs need to get from their site of synt…
  • Patient Requests for Tests and Treatments Impact Physician Management of Hypothyroidism. [Journal Article]
    Thyroid 2019Esfandiari N, Reyes-Gastelum D, … Papaleontiou M
  • CONCLUSIONS: Physicians reported patient requests for tests and treatments as a common barrier to appropriate thyroid hormone management. In some scenarios, physician adherence to patient requests may be a driver for inappropriate care and lead to harm. Understanding physician reported barriers to thyroid hormone management and factors associated with physician perception that patient requests are a barrier is key to improving patient care.
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