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971 results
  • Tiagabine add-on therapy for drug-resistant focal epilepsy. [Review]
    Cochrane Database Syst Rev 2019; 10:CD001908Bresnahan R, Martin-McGill KJ, … Marson AG
  • CONCLUSIONS: Tiagabine reduced seizure frequency but was associated with some adverse effects when used as an add-on treatment in people with drug-resistant focal epilepsy. The findings of the current review are mainly applicable to adults and adolescents, and may not necessarily be applicable to children as none of the trials included participants aged under 12 years. We found no significant differences between tiagabine and topiramate as add-on drugs; however, evidence was provided by a single trial and was therefore limited.
  • [Epilepsy and breastfeeding: from myth to reality]. [Review]
    Rev Neurol 2019; 69(2):68-76Cabo-Lopez I, Canneti B, Puy-Nunez A
  • CONCLUSIONS: Very few AEDs are incompatible with breastfeeding. The decision to breastfeed should take into account not only the AED, but also its number, dose, serum levels, transmission and elimination rates in the infant, and the conditions of the newborn infant. Ethosuximide and felbamate are probably high risk and incompatible with breastfeeding. Lamotrigine, phenobarbital, pregabalin, primidone, tiagabine, eslicarbazepine, brivaracetam, perampanel, zonisamide, lacosamide or the sporadic use of benzodiazepines in low doses are considered quite safe, with a low risk for breastfeeding. The other AEDs present a very low risk for breastfeeding.
  • Can Slow-Wave Sleep Enhancement Improve Memory? A Review of Current Approaches and Cognitive Outcomes. [Review]
    Yale J Biol Med 2019; 92(1):63-80Zhang Y, Gruber R
  • Slow-wave sleep (SWS) is involved in the overnight consolidation of declarative memories. Recent efforts using auditory stimulation, slow-oscillatory transcranial direct current stimulation (so-tDCS), and pharmacological agents have targeted sleep slow-waves as a method for enhancing cognitive performance. However, no studies thus far have integrated current evidence to provide a preliminary revi…
  • Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study. [Journal Article]
    Hum Brain Mapp 2019; 40(4):1276-1289Darmani G, Bergmann TO, … Ziemann U
  • Brain responses to transcranial magnetic stimulation (TMS) recorded by electroencephalography (EEG) are emergent noninvasive markers of neuronal excitability and effective connectivity in humans. However, the underlying physiology of these TMS-evoked EEG potentials (TEPs) is still heavily underexplored, impeding a broad application of TEPs to study pathology in neuropsychiatric disorders. Here we…
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