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220 results
  • Antidiabetic, antioxidant and antimicrobial activities of extracts of Tephrosia bracteolata leaves. [Journal Article]
    Heliyon 2019; 5(8):e02275Egharevba GO, Dosumu OO, … Ujjukuri P
  • Plant extracts have long been used for the ethnomedical treatment of diabetes, microbial infections and as a source of antioxidant. This study was aimed at investigating the antidiabetic, antioxidant, and antimicrobial activities of the n-hexane and ethyl acetate extract of Tephrosia bracteolata leaves (TBL) as associated with the ethnobotanical knowledge of the local people of Nigeria.
  • Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents. [Journal Article]
    Int J Mol Sci 2019; 20(15)Calvo NL, Sreekumar S, … Leonardi D
  • Among different Candida species triggering vaginal candidiasis, Candida albicans is the most predominant yeast. It is commonly treated using azole drugs such as Tioconazole (TIO) and Econazole (ECO). However, their low water solubility may affect their therapeutic efficiency. Therefore, the aim of this research was to produce a novel chitosan nanocapsule based delivery system comprising of TIO or…
  • Fractional carbon dioxide laser and topical tioconazole in the treatment of fingernail onychomycosis. [Journal Article]
    Lasers Med Sci 2019; 34(9):1873-1880El-Tatawy RA, Aliweh HA, … Shams Eldeen MA
  • Onychomycosis is a common chronic-resistant nail disease. Traditional treatment has its limitations and side effects. This study aimed to evaluate the role of fractional CO2 laser and topical tioconazole 28% nail lacquer in the treatment of fingernail onychomycosis, as sole treatment modalities and in combination. Thirty patients with culture-proven onychomycosis were included and randomly divide…
  • Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. [Journal Article]
    Sci Rep 2019; 9(1):1577Jeffreys LN, Poddar H, … Munro AW
  • Flavocytochrome P450 BM3 is a natural fusion protein constructed of cytochrome P450 and NADPH-cytochrome P450 reductase domains. P450 BM3 binds and oxidizes several mid- to long-chain fatty acids, typically hydroxylating these lipids at the ω-1, ω-2 and ω-3 positions. However, protein engineering has led to variants of this enzyme that are able to bind and oxidize diverse compounds, including ste…
  • Activity of Fenticonazole, Tioconazole and Nystatin on New World Leishmania Species. [Journal Article]
    Curr Top Med Chem 2018; 18(27):2338-2346Yamamoto ES, Jesus JA, … Passero LFD
  • Leishmaniasis is an infectious disease caused by protozoal parasites belonging to Leishmania genus. Different clinical outcomes can be observed depending on the parasite species and health condition of patients. It can range from single cutaneous lesion until deadly visceral form. The treatment of all forms of leishmaniasis is based on pentavalent antimonials, and in some cases, the second-line d…
  • Therapeutic importance of synthetic thiophene. [Review]
    Chem Cent J 2018; 12(1):137Shah R, Verma PK
  • Thiophene and its substituted derivatives are very important class of heterocyclic compounds which shows interesting applications in the field of medicinal chemistry. It has made an indispensable anchor for medicinal chemists to produce combinatorial library and carry out exhaustive efforts in the search of lead molecules. It has been reported to possess a wide range of therapeutic properties wit…
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