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(tipranavir)
465 results
  • Relative Principal Components Analysis: Application to Analyzing Biomolecular Conformational Changes. [Journal Article]
    J Chem Theory Comput 2019; 15(4):2166-2178Ahmad M, Helms V, … Lengauer T
  • A new method termed "Relative Principal Components Analysis" (RPCA) is introduced that extracts optimal relevant principal components to describe the change between two data samples representing two macroscopic states. The method is widely applicable in data-driven science. Calculating the components is based on a physical framework that introduces the objective function (the Kullback-Leibler div…
  • The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta. [Journal Article]
    Toxicol Appl Pharmacol 2019; 368:18-25Karahoda R, Ceckova M, Staud F
  • In spite of remarkable reduction in the number of children born with HIV due to antiretroviral therapy, concerns remain on the short- and long-term effects of antiretroviral drugs at the feto-placental unit. Cardio- and skeletal myopathies have been reported in children exposed to antiretroviral drugs prenatally. These conditions have also been described in perturbed placental transfer of l-carni…
  • Drugs and Lactation Database (LactMed): Tipranavir [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • In the United States and other developed countries, HIV-infected mothers should generally not breastfeed their infants. No published information is available on the use of tipranavir during breastfeeding. In countries in which no acceptable, feasible, sustainable and safe replacement feeding is available, World Health Organization guidelines recommend that all women with an HIV infection who are …
  • Core-shell nanoparticles for targeted and combination antiretroviral activity in gut-homing T cells. [Journal Article]
    Nanomedicine 2018; 14(7):2143-2153Cao S, Jiang Y, … Woodrow KA
  • A major sanctuary site for HIV infection is the gut-associated lymphoid tissue (GALT). The α4β7 integrin gut homing receptor is a promising therapeutic target for the virus reservoir because it leads to migration of infected cells to the GALT and facilitates HIV infection. Here, we developed a core-shell nanoparticle incorporating the α4β7 monoclonal antibody (mAb) as a dual-functional ligand for…
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