- Plasma total prion protein as a potential biomarker for neurodegenerative dementia: diagnostic accuracy in the spectrum of prion diseases. [Journal Article]
- NANeuropathol Appl Neurobiol 2019 Jun 19
- CONCLUSIONS: Plasma t-PrP is elevated in prion diseases regardless of aetiology. This pilot diagnostic accuracy values open the possibility to consider plasma t-PrP as a promising blood-based biomarker in the diagnostic of prion disease. This article is protected by copyright. All rights reserved.
- Rac GTPase-Activating Protein 1 (RACGAP1) as an Oncogenic Enhancer in Esophageal Carcinoma. [Journal Article]
- OOncology 2019 Jun 19; :1-9
- CONCLUSIONS: RACGAP1 plays a pivotal role in EC development, suggesting that it could be used as an indicator of prognosis in EC patients.
- Dystrophic Calcification of the Bladder after Photovaporization of the Prostate with GreenLightTM Laser 180 W: A Case Report. [Case Reports]
- UIUrol Int 2019 Jun 19; :1-3
- A 69-year-old patient who underwent photovaporization of the prostate (PVP) with GreenLightTM Laser presented chronic abdominal pain, in the following and after 7 months, an abdominal MRI showed a bl…
A 69-year-old patient who underwent photovaporization of the prostate (PVP) with GreenLightTM Laser presented chronic abdominal pain, in the following and after 7 months, an abdominal MRI showed a bladder mass and the cystoscopy revealed an 8 cm of diameter grayish mass of the anterior wall and the dome. Malignancy, infectious, and granulomatous diseases were ruled out. Biopsy showed necrotic tissue and dystrophic calcification (DC) with crystals and Gram-positive cocci, so a transurethral resection was intended failed due to the mass hard consistency and size. The patient was taken to partial cystectomy and the pain resolved. DC is defined as inappropriate deposits of calcium phosphate salts in previously damaged tissue by different forms of trauma: burns, radiotherapy, and surgery. We suggest the DC process is linked to a previous thermal lesion of the bladder during PVP and believe future studies of association can be relevant.
- Trimming of Absorbable Plates and Screws through Smoothing by Multiple Sonic Activation Procedures Can Increase Local Tissue Reactions in Children with Cranial Fixations. [Journal Article]
- PNPediatr Neurosurg 2019 Jun 19; :1-5
- CONCLUSIONS: It was concluded that drilling rather than smoothing by MSAP to change the shapes of the absorbable plates and screws in cranial fixation can reduce the local reactions.
- Collateral Automation for Triage in Stroke: Evaluating Automated Scoring of Collaterals in Acute Stroke on Computed Tomography Scans. [Journal Article]
- CDCerebrovasc Dis 2019 Jun 19; :1-6
- Computed tomography angiography (CTA) collateral scoring can identify patients most likely to benefit from mechanical thrombectomy and those more likely to have good outcomes and ranges from 0 (no co…
Computed tomography angiography (CTA) collateral scoring can identify patients most likely to benefit from mechanical thrombectomy and those more likely to have good outcomes and ranges from 0 (no collaterals) to 3 (complete collaterals). In this study, we used a machine learning approach to categorise the degree of collateral flow in 98 patients who were eligible for mechanical thrombectomy and generate an e-CTA collateral score (CTA-CS) for each patient (e-STROKE SUITE, Brainomix Ltd., Oxford, UK). Three experienced neuroradiologists (NRs) independently estimated the CTA-CS, first without and then with knowledge of the e-CTA output, before finally agreeing on a consensus score. Addition of the e-CTA improved the intraclass correlation coefficient (ICC) between NRs from 0.58 (0.46-0.67) to 0.77 (0.66-0.85, p = 0.003). Automated e-CTA, without NR input, agreed with the consensus score in 90% of scans with the remaining 10% within 1 point of the consensus (ICC 0.93, 0.90-0.95). Sensitivity and specificity for identifying favourable collateral flow (collateral score 2-3) were 0.99 (0.93-1.00) and 0.94 (0.70-1.00), respectively. e-CTA correlated with the Alberta Stroke Programme Early CT Score (Spearman correlation 0.46, p < 0.001) highlighting the value of good collateral flow in maintaining tissue viability prior to reperfusion. In conclusion, -e-CTA provides a real-time and fully automated approach to collateral scoring with the potential to improve consistency of image interpretation and to independently quantify collateral scores even without expert rater input.
- A novel and rapid approach to estimate patient-specific distortions based on mDIXON MRI. [Journal Article]
- PMPhys Med Biol 2019 Jun 19
- A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain. [Journal Article]
- JNJ Neural Eng 2019 Jun 19
- CONCLUSIONS: This is the first demonstration of a rat dural-penetrating array for chronic recording. This device obviates the need for a durotomy, reducing surgical time and risk of damage to the blood-brain barrier. This is an improvement to state-of-the-art flexible polymer electrode arrays that facilitates their implantation, particularly in multi-site recording experiments. This sharpening process can also be integrated into silicon electrode array fabrication.
- A new approach to the classification of muscle health: preliminary investigations. [Journal Article]
- PMPhysiol Meas 2019 Jun 19
- CONCLUSIONS: Cut-points based on Z and T-scores generated from the young adult mean suggest muscle quality demonstrates the greatest construct validity toward the aim of classifying the muscular health of adults. Data generated from large, representative and sex-specific samples are required to adequately classify the muscular health of adults.
- Multi-step material decomposition for spectral computed tomography. [Journal Article]
- PMPhys Med Biol 2019 Jun 19
- Spectral images from photon counting spectral detectors are being&#13; explored for material decomposition applications such as for obtaining quantitative&#13; maps of tissue types and contra…
Spectral images from photon counting spectral detectors are being&#13; explored for material decomposition applications such as for obtaining quantitative&#13; maps of tissue types and contrast agents. While these detectors allow acquisition&#13; of multi-energy data in a single exposure, separating the total photon counts into&#13; multiple energy bins can lead to issues of count starvation and increased quantum&#13; noise in resultant maps. Furthermore, the complex decomposition problem is often&#13; solved in a single inversion step making it dicult to separate materials with close&#13; properties. We propose a multi-step decomposition method which allows solving the&#13; problem in multiple steps using the same spectral data collected in a single exposure.&#13; During each step, quantitative accuracy of a single material is under focus and one can&#13; &#13; exibly optimize the bins chosen in that step. The result thus obtained becomes part&#13; of the input data for the next step in the multi-step process. This makes the problem&#13; less ill-conditioned and allows better quantitation of more challenging materials within&#13; the object. In comparison to a conventional single-step method, we show excellent&#13; quantitative accuracy for decomposing up to six materials involving a mix of soft&#13; tissue types and contrast agents in micro-CT sized digital phantoms.
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- The impact of anthropogenic food subsidies on a generalist seabird during nestling growth. [Journal Article]
- STSci Total Environ 2019 Jun 05; 687:546-553
- Anthropogenic food subsidies, such as refuse, are an important driver of animal population changes and gulls heavily forage on this food source. Foraging on refuse during the rearing period could aff…
Anthropogenic food subsidies, such as refuse, are an important driver of animal population changes and gulls heavily forage on this food source. Foraging on refuse during the rearing period could affect the acquisition of resources with potential demographic consequences. Using conventional diet analysis and stable isotopes of δ13C and δ15N of blood of Kelp Gull (Larus dominicanus) nestlings, we studied the variation of the chick growth in response to foraging on refuse on a reproductive colony in the Rio de la Plata Estuary in Uruguay. Using Bayesian mixing models on isotopic data, we estimated the proportion and variation of natural food and refuse in the diet of nestlings. Then, we modelled the variation between the mean posterior densities of the food sources and their standard deviation with the nestling morphometric measurements of different sizes. We found that refuse was gradually delivered to Kelp Gull nestlings during the chick rearing period. Additionally, variation of refuse incorporated into nestling tissues increased with nestlings' size. We propose that parents use more isotopically unique food sources during the nestling growth thereby increasing isotopic diversity. This study highlights the need to improve the current waste management system, which is being reviewed in Uruguay. We believe that decision makers should consider the results of this study, which show that refuse is directly impacting coastal ecosystems through mechanisms poorly explored by the environmental sciences.