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Unbound Medicine.
(tobramycin)
7,813 results
  • Comparison of Vancomycin Pharmacokinetics in Cystic Fibrosis Patients Pre and Post-lung Transplant. [Journal Article]
    Clin Med Insights Circ Respir Pulm Med. 2020; 14:1179548420930925.White S, Sakon C, … Wong A
  • CONCLUSIONS: Vancomycin pharmacokinetics are significantly altered in CF patients in the posttransplant setting as evidenced by a decrease in elimination rate constant. This decrease may be related to a decrease in renal clearance and higher numbers of nephrotoxic medications posttransplant. Regardless, pretransplant vancomycin regimens may not predict appropriate posttransplant regimens.
  • Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. [Journal Article]
    Nat Commun. 2020 Jun 22; 11(1):3162.Wang C, Li Y, … Zhang N
  • Interacting with proteins is a crucial way for long noncoding RNAs (lncRNAs) to exert their biological responses. Here we report a high throughput strategy to characterize lncRNA interacting proteins in vivo by combining tobramycin affinity purification and mass spectrometric analysis (TOBAP-MS). Using this method, we identify 140 candidate binding proteins for lncRNA highly upregulated in liver …
  • Novel Aminoglycoside Tolerant "Phoenix" Colony Variants of Pseudomonas aeruginosa. [Journal Article]
    Antimicrob Agents Chemother. 2020 Jun 15 [Online ahead of print]Sindeldecker D, Moore K, … Stoodley P
  • Pseudomonas aeruginosa is an opportunistic bacterial pathogen and is known to produce biofilms. We have previously shown the emergence of colony variants in the presence of tobramycin-loaded calcium sulfate beads. In this study, we characterized the variant colonies, which survived the antibiotic treatment and identified three distinct phenotypes - classically resistant colonies, viable but non-c…
  • Prediction of Antimicrobial Resistance in Gram-Negative Bacteria From Whole-Genome Sequencing Data. [Journal Article]
    Front Microbiol. 2020; 11:1013.Van Camp PJ, Haslam DB, Porollo A
  • CONCLUSIONS: Whole genome sequencing enables the prediction of antimicrobial resistance in Gram-negative bacteria. We present a tool that provides an in silico antibiogram for eight drugs. Predictions are accompanied with a reliability index that may further facilitate the decision making process. The demo version of the tool with pre-processed samples is available at https://vancampn.shinyapps.io/wgs2amr/. The stand-alone version of the predictor is available at https://github.com/pieterjanvc/wgs2amr/.
  • [Treatment refractory multidrug-resistant bacterial keratitis]. [Journal Article]
    Ophthalmologe. 2020 Jun 10 [Online ahead of print]Schubert F, Sekundo W, Paul C
  • This article reports a case of severe, treatment refractory infectious keratitis. Multiple samples of the cornea and the anterior chamber were taken without detection of any pathogens. Ultimately a multidrug-resistant Pseudomonas aeruginosa was isolated and successfully treated with tobramycin and amikacin, according to its antibiotic sensitivity. If there is a clinical suspicion multiple samples…
  • Pseudomonas aeruginosa biofilm eradication via nitric oxide-releasing cyclodextrins. [Journal Article]
    ACS Infect Dis. 2020 Jun 08 [Online ahead of print]Rouillard K, Markovetz MR, … Schoenfisch MH
  • Pseudomonas aeruginosa is the main contributor to the morbidity and mortality of cystic fibrosis (CF) patients. Chronic respiratory infections are rarely eradicated due to protection from CF mucus and the biofilm matrix. The composition of the biofilm matrix determines its viscoelastic properties and affects antibiotic efficacy. Nitric oxide (NO) can both disrupt the physical structure of the bio…
  • Parallel Evolution of Tobramycin Resistance across Species and Environments. [Journal Article]
    mBio. 2020 May 26; 11(3)Scribner MR, Santos-Lopez A, … Cooper VS
  • Different species exposed to a common stress may adapt by mutations in shared pathways or in unique systems, depending on how past environments have molded their genomes. Understanding how diverse bacterial pathogens evolve in response to an antimicrobial treatment is a pressing example of this problem, where discovery of molecular parallelism could lead to clinically useful predictions. Evolutio…
  • Safety of Antimicrobials During Pregnancy: A Systematic Review of Antimicrobials Considered for Treatment and Postexposure Prophylaxis of Plague. [Journal Article]
    Clin Infect Dis. 2020 May 21; 70(Supplement_1):S37-S50.Yu PA, Tran EL, … Meaney-Delman D
  • CONCLUSIONS: For most antimicrobials reviewed, adverse maternal/fetal/neonatal outcomes were not observed consistently. Prenatal exposure to streptomycin and TMP-SMX was associated with select birth defects in some studies. Based on limited data, chloramphenicol and doxycycline may be associated with adverse pregnancy or neonatal outcomes; however, more data are needed to confirm these associations. Antimicrobials should be used for treatment and PEP of plague during pregnancy; the choice of antimicrobials may be influenced by these data as well as information about the risks of plague during pregnancy.
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