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(topotecan)
3,247 results
  • Treatment of recurrent epithelial ovarian cancer. [Review]
    Cancer 2019; 125 Suppl 24:4609-4615Pignata S, Pisano C, … Attademo L
  • The majority of patients with advanced ovarian cancer progress after first-line therapy and require further treatment. Tumor biology, prior chemotherapy, responses to previous therapy, performance status, and toxicity are the characteristics that influence treatment choice. These criteria have been linked to the time between relapse and last platinum therapy: the platinum-free interval. Today, pa…
  • Molecular mechanism of C-phycocyanin induced apoptosis in LNCaP cells. [Journal Article]
    Bioorg Med Chem 2020; 28(3):115272Kaur P, Dhandayuthapani S, … Rathinavelu A
  • The usefulness of Marine-derived products as the source of anticancer agents has been explored for many decades. The objective of our study was to investigate the molecular mechanism by which C-PC induces apoptosis in monotherapy as well as in combination treatment with a known chemotherapeutic drug named Topotecan (TPT) using prostate cancer cells (LNCaP). To determine the intracellular mechanis…
  • Targeting Tyrosyl-DNA phosphodiesterase I to enhance toxicity of phosphodiester linked DNA-adducts. [Journal Article]
    Cancer Drug Resist 2019; 2:1153-1163Brettrager EJ, van Waardenburg RCAM
  • Our genomic DNA is under constant assault from endogenous and exogenous sources, which needs to be resolved to maintain cellular homeostasis. The eukaryotic DNA repair enzyme Tyrosyl-DNA phosphodiesterase I (Tdp1) catalyzes the hydrolysis of phosphodiester bonds that covalently link adducts to DNA-ends. Tdp1 utilizes two catalytic histidines to resolve a growing list of DNA-adducts. These DNA-add…
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