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348,893 results
  • Shiga toxin induces lipid compression: a mechanism for generating membrane curvature. [Journal Article]
    Nano Lett 2019Watkins EB, Majewski J, … Johannes L
  • Bio-membranes are hard to compress laterally and membrane area compressibility has not been associated with biological processes. Using x-ray surface scattering, we observed that bacterial Shiga toxin compresses lipid packing in a gel phase monolayer upon binding to its cellular receptor, the glycolipid Gb3. This toxin induced reorganization of lipid packing reached beyond the immediate membrane …
  • Pharmacotherapy Options in the Management of Raynaud's Phenomenon. [Journal Article]
    Curr Treatm Opt Rheumatol 2018; 4(3):235-254Hinze AM, Wigley FM
  • Multiple classes of medications have been studied for the treatment of Raynaud's phenomenon (RP) with or without digital ischemia. The goal of this review is to discuss the outcomes of recent studies and to report on our approach to the management of RP in light of the available evidence.
  • Genetic platelet depletion is superior in platelet transfusion compared to current models. [Journal Article]
    Haematologica 2019Salzmann M, Schrottmaier WC, … Assinger A
  • Genetically modified mice advanced our knowledge on platelets in hemostasis and beyond tremendously. However, mouse models harbor certain limitations, including availability of platelet specific transgenic strains, and off-target effects on other cell types. Transfusion of genetically modified platelets into thrombocytopenic mice circumvents these problems. Additionally, ex vivo treatment of plat…
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