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(toxin antitoxin)
8,088 results
  • Effect of Endogenous Clostridioides difficile Toxin Antibodies on Recurrence of C. difficile Infection. [Journal Article]
    Clin Infect Dis 2019Kelly CP, Poxton IR, … Dorr MB
  • CONCLUSIONS: Higher eAb titers against toxin B, but not toxin A, were associated with protection against rCDI. These data are consistent with the observed efficacy of bezlotoxumab, and lack of efficacy of actoxumab, in the MODIFY trials.High titers of endogenous antibodies to Clostridioides difficile toxin B, but not toxin A, were associated with reduced recurrence of C. difficile infection. These findings are consistent with efficacy data from the phase 3 MODIFY trials of bezlotoxumab and actoxumab.
  • Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans. [Journal Article]
    Emerg Infect Dis 2019; 25(11):2122-2123Otsuji K, Fukuda K, … Saito M
  • Corynebacterium ulcerans infection is emerging in humans. We conducted phylogenetic analyses of C. ulcerans and C. diptheriae, which revealed diverse diphtheria toxin in C. ulcerans. Diphtheria toxin diversification could decrease effectiveness of diphtheria toxoid vaccine and diphtheria antitoxin for preventing and treating illnesses caused by this bacterium.
  • Genetic Characterization of Plasmid-Borne bla OXA-58 in Distinct Acinetobacter Species. [Journal Article]
    mSphere 2019; 4(5)Matos AP, Cayô R, … Gales AC
  • We characterize by whole-plasmid-sequence (WPS) two-plasmid-borne bla OXA-58 obtained from Acinetobacter seifertii (Asp-1069) and A. baumannii (Acb-45063) clinical strains recovered 17 years apart from distinct Brazilian regions. Multilocus sequence type (MLST) analysis showed that the Asp-1069 and Acb-45063 strains belong to ST551 and ST15/CC15, respectively. WPS analysis demonstrated that bla O…
  • [Diphtheria: a 'forgotten' disease?] [Journal Article]
    Ned Tijdschr Geneeskd 2019; 163Rümke LW, Rümke HC
  • Respiratory diphtheria is an acute respiratory tract infection. The high mortality rates (5-10%) are related to airway obstruction and local and systemic effects of the diphtheria toxin. Vaccination against diphtheria has been available through the Dutch national vaccination programme since the 1950s. The disease has now become rare as a result of herd immunity by these vaccinations. As a consequ…
  • Measuring Plasmid Stability in Gram-Negative Bacteria. [Journal Article]
    Methods Mol Biol 2020; 2075:223-233Lobato-Márquez D
  • In this chapter, a highly sensitive method to measure plasmid stability in Gram-negative bacteria is described. This procedure is based on the counterselection of plasmid-containing cells using an aph-parE cassette. When bacteria carrying the aph-parE module in the plasmid of interest are grown in media containing rhamnose as the only carbon source, the PparE promoter is induced, ParE is synthesi…
  • Type I toxin-dependent generation of superoxide affects the persister life cycle of Escherichia coli. [Journal Article]
    Sci Rep 2019; 9(1):14256Edelmann D, Berghoff BA
  • Induction of growth stasis by bacterial toxins from chromosomal toxin-antitoxin systems is suspected to favor formation of multidrug-tolerant cells, named persisters. Recurrent infections are often attributed to resuscitation and regrowth of persisters upon termination of antibiotic therapy. Several lines of evidence point to oxidative stress as a crucial factor during the persister life cycle. H…
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