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2,037 results
  • Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient. [Journal Article]
    Clin Neuropharmacol 2020 Jan/Feb; 43(1):31-33Warnant A, Gerard L, … Hantson P
  • A 77-year-old woman developed a deep coma (Glasgow Coma Scale score at 3/15) after a trazodone overdose (maximal ingested dose, 4500 mg), and orotracheal intubation was required for mechanical ventilation. In addition, she presented sinus bradycardia (<40/min) with QTc prolongation, whereas arterial blood pressure was preserved. The administration of intravenous lipid emulsion (1.5 mL/kg as a bol…
  • Management of insomnia in alcohol use disorder. [Journal Article]
    Expert Opin Pharmacother 2020; 21(3):297-306Geoffroy PA, Lejoyeux M, Rolland B
  • Introduction: Insomnia has been implicated in the development, maintenance, worsening, and relapse of alcohol use disorder (AUD).Areas covered: The authors review the possible pharmacological and non-pharmacological treatment options of insomnia for patients with alcohol-use disorder and provide their expert opinion.Expert opinion: Abstinence, or at least a decrease in alcohol use, may improve in…
  • A week-long outpatient induction onto XR-naltrexone in patients with opioid use disorder. [Journal Article]
    Am J Drug Alcohol Abuse 2019; :1-8Sibai M, Mishlen K, … Bisaga A
  • CONCLUSIONS: The results support the feasibility of a week-long outpatient induction onto XR-naltrexone with ascending doses of naltrexone and standing doses of adjunctive medications. By circumventing the need for a protracted period of abstinence and mitigating the severity of withdrawal symptoms experienced during naltrexone titration, this strategy has the potential to increase patient acceptability and access to relapse prevention treatment with XR-naltrexone.
  • Interventions to reduce bruxism in children and adolescents: a systematic scoping review and critical reflection. [Review]
    Eur J Pediatr 2020; 179(2):177-189Chisini LA, San Martin AS, … Goettems ML
  • CONCLUSIONS: Several intervention options are available to inhibit or reduce bruxism activity. The respective indication, contraindications, and side effects of each treatment option must be assessed individually and carefully, taking into account that bruxism is not considered a disorder in otherwise healthy individuals.What is known• Biological and psychological factors have been strongly correlated to the development of bruxism• Bruxism prevalence ranging from 6 to 50% in childrenWhat is new• Reduction in self-reported bruxism and headaches associated with bruxism were observed in studies that used medication (Hydroxyzine/ Trazodone/ Flurazepam), occlusal splints, orthodontic interventions, psychological, and physical therapy interventions• A reduction in Rhythmic Masticatory Muscle Activity was observed with the use of the occlusal splint and orthodontic interventions. Alternative treatments (medicinal extracts such as Melissa officinalis L) show inconclusive results in respect of the reduction in bruxism.
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