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Unbound Medicine.
(trabecular meshwork)
5,968 results
  • Ripasudil Hydrochloride Hydrate in the Treatment of Glaucoma: Safety, Efficacy, and Patient Selection. [Review]
    Clin Ophthalmol. 2020; 14:1229-1236.Kusuhara S, Nakamura M
  • Reduction of intraocular pressure (IOP) is the only reliable treatment for glaucoma that maintains the patient's visual function throughout life, and IOP-lowering eyedrops are the mainstay of therapy. Ripasudil hydrochloride hydrate (brand name: Glanatec ophthalmic solution 0.4%; Kowa Company, Ltd., Japan) is a Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor that lowers IO…
  • Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 May 21 [Online ahead of print]Patel G, Fury W, … Romano C
  • The conventional outflow pathway is a complex tissue responsible for maintaining intraocular pressure (IOP) homeostasis. The coordinated effort of multiple cells with differing responsibilities ensures healthy outflow function and IOP maintenance. Dysfunction of one or more resident cell types results in ocular hypertension and risk for glaucoma, a leading cause of blindness. In this study, singl…
  • A Prospective Analysis of iStent Inject Microstent Implantation: Surgical Outcomes, Endothelial Cell Density, and Device Position at 12 Months. [Journal Article]
    J Glaucoma. 2020 May 19 [Online ahead of print]Gillmann K, Mansouri K, … Mermoud A
  • CONCLUSIONS: The surgical outcome of iStent inject devices is associated with device protrusion within the anterior chamber. Schlemm canal (SC) dilatation has a prognostic value. iStent inject devices do not move within the first year after implantation.This study demonstrates the IOP-lowering and medication-lowering potential of iStent inject surgery in primary open-angle and pseudoexfoliative glaucoma. It confirms that surgical outcomes are positively associated with device protrusion within the anterior chamber, and suggests SC dilatation effect as a favorable prognostic indicator. It shows that stents are stable in time, highlighting the importance of the initial implantation location.
  • ABCA1 Regulates IOP by Modulating Cav1/eNOS/NO Signaling Pathway. [Journal Article]
    Invest Ophthalmol Vis Sci. 2020 May 11; 61(5):33.Hu C, Niu L, … Sun X
  • CONCLUSIONS: Regulation of aqueous humor outflow via the caveolin-1/endothelial NO synthase/NO pathway is a newly defined function of ABCA1 that is different from its traditional role in mediating cholesterol efflux. ABCA1 is a compelling, novel therapeutic candidate for the treatment of glaucoma and ocular hypertension.
  • lncRNA TGFβ2-AS1 promotes ECM production via TGF-β2 in human trabecular meshwork cells. [Journal Article]
    Biochem Biophys Res Commun. 2020 May 16 [Online ahead of print]Lv Y, Zhang Z, … Liu A
  • Evidence indicates that long noncoding RNAs (lncRNAs) participate in the regulation of various physiological and pathological processes including organ fibrosis and eye-related diseases. The important pathological manifestations of open-angle glaucoma (OAG) are human trabecular meshwork cells (HTMCs) apoptosis and excessive deposition of extracellular matrix (ECM) components in TM, which can caus…
  • An Insight into Primary Congenital Glaucoma. [Journal Article]
    Crit Rev Eukaryot Gene Expr. 2020; 30(1):39-43.Khan MU, Zia MUQ, Tabassum W
  • Glaucoma is the second most prominent cause of impaired vision in the world. Over 60 million individuals are presently affected, and 12 million are sightless as a result. Primary congenital glaucoma (PCG) is a childhood disease that can lead to blindness in newborns and very young children. The rate of occurrence of PCG varies in different communities and across geographical boundaries, and its e…
  • Cross-talk between MYOC p. Y437H mutation and TGF-β2 in the pathology of glaucoma. [Journal Article]
    Int J Med Sci. 2020; 17(8):1062-1070.Yang Y, Abdulatef ASWA, … Xia X
  • Objective: To identify the interaction between the MYOC Y437H mutation and TGF-β2 in a family with primary open-angle glaucoma (POAG). Methods: The MYOC Y437H mutation was identified in a family with POAG; the family was a fourth-generation family with 27 members, of which 6 members were affected. Analysis focused on the secreted myocilin protein and TGF-β2 found in the aqueous humor. Samples wer…
  • Nitric oxide donating anti-glaucoma drugs: advances and prospects. [Journal Article]
    Chin J Nat Med. 2020 Apr; 18(4):275-283.Mao YJ, Wu JB, … Huang ZJ
  • Glaucoma is a disease that causes irreversible blindness. Reducing intraocular pressure (IOP) is the main treatment at present. Nitric oxide (NO), an endogenous gas signaling molecule, can increase aqueous humor outflow facility, inhibit aqueous humor production thereby reducing IOP, as well as regulate eye blood flow and protect the optic nerve. Therefore, NO donating anti-glaucoma drugs have br…
  • Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma. [Journal Article]
    Ocul Immunol Inflamm. 2020 May 13 [Online ahead of print]Schultheiss M, Voykov B, … Casagrande M
  • Purpose: Investigating the existence of inflammation in the distal outflow system posterior of the Schlemm's canal in primary open-angle glaucoma (POAG).Methods: Scleral biopsies (n = 62) from POAG-patients were taken during deep sclerectomy and fixed either in formalin or RNAlater®. Histologic (hematoxylin & eosin) and immunohistological staining for CD 3 and CD 45RO were performed.Results: Cell…
  • Current review of Excimer laser Trabeculostomy. [Review]
    Eye Vis (Lond). 2020; 7:24.Durr GM, Töteberg-Harms M, … Ahmed IIK
  • CONCLUSIONS: Current literature shows a significant IOP-lowering effect of ELT with a favorable safety-profile in standalone cases or combined with cataract surgery. Limitations to these studies are the lack of controls and washout IOP. Overall, ELT is an attractive MIGS option that does not require any residual device remaining in the angle.
  • AP-2β is required for formation of the murine trabecular meshwork and Schlemm's canal. [Journal Article]
    Exp Eye Res. 2020 Apr 27; 195:108042.Akula M, Taiyab A, … West-Mays JA
  • Previously, we have shown that Tfap2b, the gene encoding transcription factor AP-2β, is needed for normal mouse eye development. Specifically, targeted loss of Tfap2b in neural crest cells (NCCs)1 and their derivatives, particularly the periocular mesenchyme (POM), resulted in anterior segment defects affecting the cornea and angle tissue. These defects were further associated with an increase in…
  • Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma. [Journal Article]
    Sci Rep. 2020 Apr 28; 10(1):7115.Choi W, Bae HW, … Seong GJ
  • This study evaluated age-related trabecular meshwork (TM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance Hospital between January 2015 and June 2019. We randomly included 250 eyes of 125 patients who unde…
  • Involvement of autotaxin in the pathophysiology of elevated intraocular pressure in Posner-Schlossman syndrome. [Journal Article]
    Sci Rep. 2020 Apr 14; 10(1):6265.Igarashi N, Honjo M, … Aihara M
  • To examine whether autotaxin (ATX) in the aqueous humor causes elevated intraocular pressure (IOP) in patients with Posner-Schlossman syndrome (PSS). ATX and transforming growth factor beta (TGF-β) in the aqueous humor were quantified in PSS patients. The expression of ATX and TGF-β in cytomegalovirus (CMV)-infected-human trabecular meshwork (hTM) cells was examined. Biological changes in hTM cel…
  • Adipose-derived stem cells integrate into trabecular meshwork with glaucoma treatment potential. [Journal Article]
    FASEB J. 2020 May; 34(5):7160-7177.Zhou Y, Xia X, … Du Y
  • The trabecular meshwork (TM) is an ocular tissue that maintains intraocular pressure (IOP) within a physiologic range. Glaucoma patients have reduced TM cellularity and, frequently, elevated IOP. To establish a stem cell-based approach to restoring TM function and normalizing IOP, human adipose-derived stem cells (ADSCs) were induced to differentiate to TM cells in vitro. These ADSC-TM cells disp…
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