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227,526 results
  • [Possibilities of using Mexidol in the complex therapy of mental disorders]. [Review]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2020; 120(5):160-164.Shamrey VK, Kurasov ES, … Tsygan NV
  • A review of the current literature on the possible use of mexidol (ethylmethylhydroxypyridine succinate) in the treatment of mental (including addictive) disorders is conducted. The possibility of its use to reduce negative psychopathological symptoms, neurocognitive deficit, manifestations of the antipsychotic syndrome (including its extrapyramidal disorders) in antipsychotic treatment of patien…
  • Efficacy and safety of dopamine agonists in patients treated with antipsychotics and presenting a macroprolactinoma. [Multicenter Study]
    Eur J Endocrinol. 2020 Aug 01; 183(2):221-231.Allard L, Albarel F, … Chanson P
  • CONCLUSIONS: Even if the DA efficacy on PRL levels and tumor volume in patients with macroprolactinoma under antipsychotic drugs is less impressive than that typically observed, it may be considered satisfactory for half of our patients, particularly in cases of optic chiasm compression. Psychotic exacerbation was unusual in these patients, occurring mostly in those with the most severe psychotic forms. DAs may therefore be used as antitumor treatment for macroprolactinoma in patients with visual involvement, severe headaches or invasion into the skull base who receive antipsychotics.
  • Importance of adherence to treatment with direct-acting antivirals in hepatitis C. [Review]
    Gastroenterol Hepatol. 2019 Sep; 42 Suppl 1:14-19.Monte-Boquet E, Verdugo RM, … Ventayol P
  • The introduction of direct-acting antivirals (DAA) and the implementation of the National Strategic Plan has extended the spectrum of patients suitable for treatment to include practically all affected individuals. There has been a change in patient profile. Most patients are previously untreated, with lesser awareness of the disease, and taking polymedication, and are often under treatment with …
  • Neurotropism of SARS-CoV-2: COVID-19 presenting with an acute manic episode. [Case Reports]
    BMJ Case Rep. 2020 Jun 14; 13(6)Mawhinney JA, Wilcock C, … Roshanzamir S
  • A 41-year-old man with no significant medical history presented with acute behavioural disruption on the background of a 1-day history of severe headache and a 10-day history of dry cough and fever. He was sexually disinhibited with pressured speech and grandiose ideas. His behaviour worsened, necessitating heavy sedation and transfer to intensive care for mechanical ventilation despite no respir…
  • Remimazolam; a role for anaesthesia/ sedation? [Journal Article]
    Curr Opin Anaesthesiol. 2020 Jun 08 [Online ahead of print]Sneyd JR, Rigby-Jones AE
  • CONCLUSIONS: Remimazolam provides effective procedural sedation with superior success rates and recovery profile when compared to midazolam. Comparisons with propofol are required. Preliminary studies suggest potential for using remimazolam as the hypnotic component of general anaesthesia. Definitive studies are awaited. As a benzodiazepine, remimazolam could be evaluated as an anticonvulsant and for intensive care sedation.
  • Alcohol and the Hospitalized Patient. [Review]
    Med Clin North Am. 2020 Jul; 104(4):681-694.Chernyavsky S, Dharapak P, … Rizk D
  • Alcohol use is a common social and recreational activity in our society. Misuse of alcohol can lead to significant medical comorbidities that can affect essentially every organ system and lead to high health care costs and utilization. Heavy alcohol use across the spectrum from binge drinking and intoxication to chronic alcohol use disorder can lead to high morbidity and mortality both in the lon…
  • SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human Chromosome 1. [Journal Article]
    In Vivo. 2020 Jun; 34(3 Suppl):1629-1632.Lehrer S, Rheinstein PH
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19) pandemic. In the current analysis, we searched for SARS-CoV-2 sequences within the human genome. To compare the SARS-CoV-2 genome to the human genome, we used the blast-like alignment tool (BLAT) of the U…
  • Determinants of substance use among high school students in Jordan. [Journal Article]
    Curr Drug Res Rev. 2020 May 25 [Online ahead of print]Hamdan-Mansour AM, Al-Sagarat AY, … Al Thawabieh SS
  • CONCLUSIONS: High school students are at risk for use of various forms of substances and mainly the over counter ones. Legitimate rules of screening and using substance prevention programs at high schools considering the psychological factors is a priority for school health professionals and policy makers.
  • Clozapine Improves Behavioral and Biochemical Outcomes in a MK-801-Induced Mouse Model of Schizophrenia. [Journal Article]
    J Environ Pathol Toxicol Oncol. 2020; 39(1):1-12.Andrabi SS, Vishnoi S, … Parvez S
  • Glutamatergic N-methyl-D-aspartate (NMDA) receptors have critical roles in several neurological and psychiatric diseases. Dizocilpine (MK-801) is a ligand at phencyclidine recognition sites that is associated with NMDA receptor-coupled cation channels, where it acts as a potent noncompetitive antagonist of central glutamate receptors. In this study, we investigate the effect of clozapine on MK-80…
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