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1,049,678 results
  • Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death. [Journal Article]
    Cells 2020; 9(1)Han S, Nandy P, … Zhu X
  • It is believed that mitochondrial fragmentation cause mitochondrial dysfunction and neuronal deficits in Alzheimer's disease. We recently reported that constitutive knockout of the mitochondria fusion protein mitofusin2 (Mfn2) in the mouse brain causes mitochondrial fragmentation and neurodegeneration in the hippocampus and cortex. Here, we utilize an inducible mouse model to knock out Mfn2 (Mfn2…
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