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846,807 results
  • StatPearls: Lung Volume Reduction Surgery [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Lee Madonna M Seattle Children’s Mora Carpio Andres L. AL BOOK
  • Lung volume reduction surgery (LVRS) is a surgical procedure considered for patients with chronic obstructive pulmonary disease (COPD) or severe emphysema.[1] Although first described in the 1950s, it did not gain popularity until the 1990s, due to improved surgical technology and management of complications.[2] A large, collaborative, multicenter, randomized control trial for LVRS, known as the …
  • StatPearls: Rhinocerebral Mucormycosis [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Bhandari Jenish J Punjab Medical College/Univeristy of Health Scienes Thada Pawan K. PK Punjab Medical College/University of Health Sciences Nagalli Shivaraj S Yuma Regional Medical Center BOOK
  • Rhinocerebral mucormycosis, also called zygomycosis, is a rare disease caused by filamentous fungi involving the nose, paranasal sinuses, and brain. It is an opportunistic pathogen commonly found in immunocompromised individuals. Because of its involvement with already immunocompromised patients, the fungus grows rapidly and aggressively, causing a well-defined fulminant and life-threatening dise…
  • StatPearls: Cartilage Graft [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Davis Donald D. DD Wellstar Atlanta Medical Center Kane Steven M. SM Wellstar Atlanta Medical Center BOOK
  • Joint pain is a complex problem facing medical practitioners that has its origin in a host of conditions, injuries, and diseases. Between the years of 2013 and 2015 alone, an estimated 54.4 million United States (US) adults (22.7%) annually were told by a doctor that they had some form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia.[1]  Physicians, researchers, and other medical…
  • StatPearls: Heart-Lung Transplantation [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Tully Andy A UIC Nagalli Shivaraj S Yuma Regional Medical Center BOOK
  • Pioneered in the 1960s, and successfully implemented in the 1980s, with a declining number of candidates since the 1990s,[1] simultaneous heart and lung transplantation is only indicated for patients in the end stages of both cardiac and pulmonary failure. If only one of the two thoracic organ systems has irreversibly failed and the other is salvageable, then most treatment centers forego dual tr…
  • StatPearls: Liver Transplantation [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Dababneh Yara Y The Hashemite University Mousa Omar Y. OY Mayo Clinic BOOK
  • Cirrhosis and decompensated liver disease were the ninth leading cause of death for males in 2016 in the United States.[1] Liver transplantation (LT) is a lifesaving gift and proven intervention in the management of patients with acute and chronic end-stage liver disease. It restores normal health, lifestyle, and extends lifespan by 15 years.[2] The advent of LT came as a safety net to treat a va…
  • Healthcare interventions improving and reducing quality of life in children at the end of life: a systematic review. [Review]
    Pediatr Res. 2020 Jul 09 [Online ahead of print]Piette V, Beernaert K, … Deliens L
  • CONCLUSIONS: Use of patient-controlled symptom feedback, multidisciplinary palliative care teams with full-time practical support, inhalation therapy, and off-label sedative medication may improve QOL. Curative therapy may reduce QOL.QOL for children at the end of life may be improved with patient-controlled symptom feedback, multidisciplinary palliative care teams with full-time practical support, inhalation therapy, and off-label sedative medication.QOL for children at the end of life may be reduced with therapy with a curative intent, such as curative chemotherapy or stem cell transplant.A comprehensive overview of current evidence to elevate currently often-failing QOL management for children at the end of life.New paradigm-level indicators for appropriate and inappropriate QOL management in children at the end of life.New hypotheses for future research, guided by the current knowledge within the field.Various healthcare interventions (as described above) could or might be employed as tools to provide relief in QOL management for children with serious illness, such as cancer, at the end of life, and therefore could be discussed in pediatrician end-of-life training to limit the often failed QOL management in this population, cave the one-size-fits-all approach for individual cases.Multidisciplinary team efforts and 24/7 presence, especially practical support for parents, might characterize effective palliative care team interventions for children with serious illness at the end of life, suggesting a co-regulating link between well-being of the child partly to that of the parentsHypothesis-oriented research is needed, especially for children with nonmalignant disorders, such as genetic or neurological disorders at the end of life, as well as QOL outcomes for intervention research and psychosocial or spiritual outcomes.
  • Presence of anti-Leishmania antibodies in candidates for kidney transplantation. [Journal Article]
    Int J Infect Dis. 2020 Jul 06 [Online ahead of print]de Oliveira França A, da Cunha GMR, … Cavalheiros Dorval ME
  • CONCLUSIONS: Under immunocompromised conditions, VL is opportunistic and potentially fatal. Despite existing risks, screening for VL is not performed in asymptomatic donors and recipients. The detection of anti-Leishmania antibodies in these patients reinforces the need for infection screening before immunosuppressive treatment is initiated to reduce not only the risks of VL development and severity, but also mortality rates in cases of reactivation of latent infection.
  • Robotic Surgery for the Reconstruction of Transplant Ureteral Strictures. [Journal Article]
    Urology. 2020 Jul 06 [Online ahead of print]Kim S, Fuller TW, Buckley JC
  • CONCLUSIONS: Though a complex repair, the robot-assisted approach to transplant ureter reconstruction using either an end to side neoureterocystotomy or direct pyelo-vesicotomy is technically feasible and successful. Given the many advantages inherent in comparison to an open approach, the robotic repair offers significant advantages to both the patient and the surgeon who is experienced with robotic surgery and reconstructive principles.
  • Non-Contagious, Second COVID-19 Infection: Implications for Organ Donation Eligibility. [Letter]
    Clin Transplant. 2020 Jul 09 [Online ahead of print]Goss MB, Moreno NF, … Rana A
  • As of May 19, 2020, the Korea Centers for Disease Control and Prevention (KCDC) shared evidence indicating an inability for COVID-19 patients having contracted a second infection to spread the virus. Viral samples from re-infected patients could not be grown in culture, a sign of dead virus particles, attributable to neutralizing antibodies. Accordingly, a negative COVID-19 test may no longer be …
  • Isolated Extramedullary Relapse in Acute Lymphoblastic Leukemia: What Can We Do Before and After Transplant? [Case Reports]
    Oncology (Williston Park). 2020 Feb 20; 34(2):39-43.Riviello-Goya S, Acosta-Medina AA, … Bourlon C
  • • Isolated EMR is defined as the presence of clonal blasts in any tissue other than the medullary compartment with a bone marrow evaluation with less than 5% clonal blasts and a full donor chimerism. • Patients with iEMR have shown better survival outcomes when compared to BMR and EMR and in most cases it heralds a systemic relapse. • Risk factors for iEMR include: younger age, history of EMD, po…
  • Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection. [Journal Article]
    J Clin Invest. 2020 Jul 09 [Online ahead of print]Li T, Zhang Z, … Turnquist HR
  • Alarmins, sequestered self-molecules containing damage-associated molecular patterns, are released during tissue injury to drive innate immune cell pro-inflammatory responses. Whether endogenous negative regulators controlling early immune responses are also released at the site of injury is poorly understood. Herein, we establish that the stromal cell-derived alarmin interleukin-33 (IL-33) is a …
  • The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. [Journal Article]
    EMBO Rep. 2020 Jul 09 [Online ahead of print]Yang J, Wei P, … Li B
  • The transcription factor forkhead box P3 (FOXP3) is essential for the development of regulatory T cells (Tregs) and their function in immune homeostasis. Previous studies have shown that in natural Tregs (nTregs), FOXP3 can be regulated by polyubiquitination and deubiquitination. However, the molecular players active in this pathway, especially those modulating FOXP3 by deubiquitination in the di…
  • Nanocomposite hydrogels for tissue engineering applications. [Review]
    Nanoscale. 2020 Jul 09 [Online ahead of print]Zhao H, Liu M, … Pei R
  • Tissue engineering is an important field of regenerative medicine, which combines scaffolds and cell transplantation to develop substitute tissues and/or promote tissue regeneration. Hydrogels, a three-dimensional network with high water content and biocompatibility, have been widely used as scaffolds to mimic the structure and properties of tissues. However, the low mechanical strength and limit…
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