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35,901 results
  • Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity. [Journal Article]
    Sci Rep 2020; 10(1):2587Ferraro F, Corvo I, … Álvarez G
  • Trematode infections such as schistosomiasis and fascioliasis cause significant morbidity in an estimated 250 million people worldwide and the associated agricultural losses are estimated at more than US$ 6 billion per year. Current chemotherapy is limited. Triosephosphate isomerase (TIM), an enzyme of the glycolytic pathway, has emerged as a useful drug target in many parasites, including Fascio…
  • Fish-borne trematode infections in wild fishes in Bangladesh. [Journal Article]
    Pathog Glob Health 2020; :1-8Labony SS, Alim MA, … Anisuzzaman
  • Fish-borne liver and intestinal flukes are helminth pathogens that have a negative impact on public health worldwide. We herein investigated the status of infection by the metacercariae (MC) of fish-borne trematodes (FBTs) in randomly selected freshwater wild fishes. Five species of fishes were collected and digested artificially using digestion fluid to recover MC. All fish species, namely, tict…
  • Triclabendazole for the treatment of fascioliasis. [Journal Article]
    Drugs Today (Barc) 2019; 55(12):743-752Thakare R, Dasgupta A, Chopra S
  • Fascioliasis is a neglected tropical disease that is commonly caused by flatworms affecting both domestic ruminants and humans. Fascioliasis currently affects roughly 17 million people globally with additional 180 million people at risk of developing infection. Despite the gigantic patient pool, clinicians typically have very few treatment options available. In this context, triclabendazole (Fasi…
  • Molecular diversity of Bulinus species in Madziwa area, Shamva district in Zimbabwe: implications for urogenital schistosomiasis transmission. [Journal Article]
    Parasit Vectors 2020; 13(1):14Mutsaka-Makuvaza MJ, Zhou XN, … Midzi N
  • CONCLUSIONS: The study provided new insights into the levels of genetic diversity within B. globosus and additional information on B. truncatus collected from a small geographical area in Zimbabwe. Low prevalence levels of infection observed in the snails may reflect the low transmission level of urogenital schistosomiasis in the area. Our results contribute towards the understanding of the distribution and population genetic structure of Bulinus spp. supporting the mapping of the transmission or risk of transmission of urogenital schistosomiasis, particularly in Zimbabwe.
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