- A novel synthetic strategy for styrene-butadiene-styrene tri-block copolymer with high cis-1,4 units via changing catalytic active centres. [Journal Article]
- RSR Soc Open Sci 2019; 6(6):190536
- A styrene-butadiene-styrene tri-block copolymer (SBS) with a high cis-1,4 unit content (greater than 97%) was synthesized by a novel synthetic strategy based on changing the catalytic active centres …
A styrene-butadiene-styrene tri-block copolymer (SBS) with a high cis-1,4 unit content (greater than 97%) was synthesized by a novel synthetic strategy based on changing the catalytic active centres using n-butyllithium and a nickel-based catalyst. Firstly, styrene was polymerized via anionic polymerization using butyllithium as the initiator (Li, activity centre Li) at 50°C. The obtained alkylated macroinitiator (PSLi) was aged with nickel naphthenate (Ni) and boron trifluoride etherate (B) to prepare a second reactive centre (Ni-F), which was used to initiate the polymerization of butadiene (Bd). Finally, triphenyl phosphine (PPh3) was added to adjust the electron density of the third active centre (P-Ni-F), and styrene monomer was added again to synthesize the second polystyrene block to obtain SBS. The polymerization technique presented here is simple and has an efficient initiation effect due to the high initiation activities for the different monomers. It also exhibits excellent control over the stereo-structure of the butadiene segments in the prepared copolymers, and the SBS polymers with high cis-1,4 unit content were easily achieved.
- In vivo tracking on longer retention of transplanted myocardin gene-modified adipose-derived stem cells to improve erectile dysfunction in diabetic rats. [Journal Article]
- SCStem Cell Res Ther 2019 Jul 16; 10(1):208
- CONCLUSIONS: Myocardin induced ASC differentiation towards smooth muscle-like cells and enhanced the therapeutic potential of ASCs for ameliorating ED in STZ-induced diabetic rats. Notably, in vivo small animal tracking was an effective strategy for monitoring the implanted stem cells, and this strategy might have advantages over traditional EdU assays.
- Human Platelet Lysate as a Functional Substitute for Fetal Bovine Serum in the Culture of Human Adipose Derived Stromal/Stem Cells. [Journal Article]
- CCells 2019 Jul 15; 8(7)
- CONCLUSIONS: HPLs is an effective substitute for FBS in the culture, expansion and differentiation of human ASCs suitable for pre-clinical studies; however, additional assays and analyses will be necessary to validate HPLs for clinical applications and regulatory approval.
- Targeted acquisition of Fusarium oxysporum f. sp. niveum toxin-deficient mutant and its effects on watermelon Fusarium wilt. [Journal Article]
- JAJ Agric Food Chem 2019 Jul 16
- Watermelon Fusarium wilt is a common soil-borne disease that has significantly affected its yield. In this study, fusaric acid-deficient mutant designated as △FUBT (mutated from Fusarium oxysporum f.…
Watermelon Fusarium wilt is a common soil-borne disease that has significantly affected its yield. In this study, fusaric acid-deficient mutant designated as △FUBT (mutated from Fusarium oxysporum f. sp. niveum, FON) was obtained. The △FUBT mutant showed significant decrease in fusaric acid production but maintained wild-type characteristics, such as in vitro colony morphology, size and conidiation. A field pot experiment demonstrated that △FUBT could successfully colonize the rhizosphere and the roots of watermelon, leading to significant reduction in FON colonization in watermelon plant. In addition, △FUBT inoculation significantly improved the rhizosphere micro-environment and effectively increased the resistance in watermelon. This study demonstrated that a non-pathogenic Fusarium mutant (△FUBT) could be developed as an effective microbial control agent to alleviate Fusarium wilt disease in watermelon and increase its yield.
- Concentrations of Brominated Flame Retardants in Indoor Air and Dust from Ireland reveal elevated exposure to Decabromodiphenyl Ethane. [Journal Article]
- ESEnviron Sci Technol 2019 Jul 16
- Concentrations of decabromodiphenyl ethane (DBDPE), 13 polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), were measured in indoor air and dust collected from Irish homes, cars…
Concentrations of decabromodiphenyl ethane (DBDPE), 13 polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCDD), were measured in indoor air and dust collected from Irish homes, cars, offices and primary schools during 2016-17. Median concentrations of DBDPE in air (88 pg/m3) and dust (6,500 ng/g) exceed significantly those previously reported internationally, with concentrations highest in offices and schools, suggesting DBDPE is widely used in Ireland. Median concentrations of BDE-209 in air (340 pg/m3) and dust (7,100 ng/g) exceed or are within the range of concentrations reported recently for the same microenvironments in the UK, and exceed those reported in many other countries. Concentrations of BDE-209 in cars exceeded significantly (p<0.05) those in other micro-environments. HBCDD was detected in all dust samples (median: 580 ng/g), and in 81% of air samples (median: 24 pg/m3) at concentrations similar to those reported recently for the UK and elsewhere. Estimates of exposure to DBDPE of Irish adults (92 ng/day) and toddlers (210 ng/day) as well as to BDE-209 (220 ng/day and 650 ng/day for adults and toddlers respectively) exceed substantially those reported for the UK population. Moreover, our estimates of exposure of the Irish population to tri-deca-PBDEs exceed previous estimates for Ireland via dietary exposure.
- Simultaneous onset of type 1 diabetes mellitus and silent thyroiditis under durvalumab treatment [Journal Article]
- EDEndocrinol Diabetes Metab Case Rep 2019 Jul 15; 2019(1)
- Durvalumab, a human immunoglobulin G1 kappa monoclonal antibody that blocks the interaction of programmed cell death ligand 1 (PD-L1) with the PD-1 and CD80 (B7.1) molecules, is increasingly used in …
Durvalumab, a human immunoglobulin G1 kappa monoclonal antibody that blocks the interaction of programmed cell death ligand 1 (PD-L1) with the PD-1 and CD80 (B7.1) molecules, is increasingly used in advanced neoplasias. Durvalumab use is associated with increased immune-related adverse events. We report a case of a 55-year-old man who presented to our emergency room with hyperglycaemia after receiving durvalumab for urothelial high-grade non-muscle-invasive bladder cancer. On presentation, he had polyuria, polyphagia, nausea and vomiting, and laboratory test revealed diabetic ketoacidosis (DKA). Other than durvalumab, no precipitating factors were identified. Pre-durvalumab blood glucose was normal. The patient responded to treatment with intravenous fluids, insulin and electrolyte replacement. Simultaneously, he presented a thyroid hormone pattern that evolved in 10 weeks from subclinical hyperthyroidism (initially attributed to iodinated contrast used in a previous computerised tomography) to overt hyperthyroidism and then to severe primary hypothyroidism (TSH: 34.40 µU/mL, free thyroxine (FT4): <0.23 ng/dL and free tri-iodothyronine (FT3): 0.57 pg/mL). Replacement therapy with levothyroxine was initiated. Finally, he was tested positive for anti-glutamic acid decarboxylase (GAD65), anti-thyroglobulin (Tg) and antithyroid peroxidase (TPO) antibodies (Abs) and diagnosed with type 1 diabetes mellitus (DM) and silent thyroiditis caused by durvalumab. When durvalumab was stopped, he maintained the treatment of multiple daily insulin doses and levothyroxine. Clinicians need to be alerted about the development of endocrinopathies, such as DM, DKA and primary hypothyroidism in the patients receiving durvalumab.
- Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology. [Journal Article]
- IJInt J Nanomedicine 2019; 14:4683-4695
- CONCLUSIONS: These results indicate that Tri-CL-mPEG NPs are promising in clinical applications as a controllable delivery system for hydrophobic drugs.
- Đakrông virus, a novel mobatvirus (Hantaviridae) harbored by the Stoliczka's Asian trident bat (Aselliscus stoliczkanus) in Vietnam. [Journal Article]
- SRSci Rep 2019 Jul 15; 9(1):10239
- The recent discovery of genetically distinct shrew- and mole-borne viruses belonging to the newly defined family Hantaviridae (order Bunyavirales) has spurred an extended search for hantaviruses in R…
The recent discovery of genetically distinct shrew- and mole-borne viruses belonging to the newly defined family Hantaviridae (order Bunyavirales) has spurred an extended search for hantaviruses in RNAlater®-preserved lung tissues from 215 bats (order Chiroptera) representing five families (Hipposideridae, Megadermatidae, Pteropodidae, Rhinolophidae and Vespertilionidae), collected in Vietnam during 2012 to 2014. A newly identified hantavirus, designated Đakrông virus (DKGV), was detected in one of two Stoliczka's Asian trident bats (Aselliscus stoliczkanus), from Đakrông Nature Reserve in Quảng Trị Province. Using maximum-likelihood and Bayesian methods, phylogenetic trees based on the full-length S, M and L segments showed that DKGV occupied a basal position with other mobatviruses, suggesting that primordial hantaviruses may have been hosted by ancestral bats.
- Poland syndrome in an 18-year-old man. [Journal Article]
- CMAJCMAJ 2019 Jul 15; 191(28):E793
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- Vaginoscopic hysteroscopy in management for women with post-menopausal vaginal bleeding. [Journal Article]
- TJTaiwan J Obstet Gynecol 2019; 58(4):497-500
- CONCLUSIONS: The Vaginoscopic hysteroscopy combined endometrial biopsy is safe and feasible for assessment of endometrial pathology with postmenopausal bleeding.