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30 results
  • Combining a synthetic spermicide with a natural trichomonacide for safe, prophylactic contraception. [Journal Article]
    Hum Reprod. 2014 Feb; 29(2):242-52.Jain A, Kumar L, … Gupta G
  • CONCLUSIONS: A 1:1 (w/w) combination of DSE-37 and Sapindus saponins can target sperm and Trichomonas vaginalis precisely without any noticeable off-target effects on somatic cells at effective concentrations.The number of animals used for the in vivo efficacy study was limited by the approval of the animal ethics committee.Anti-Trichomonal contraceptives with specifically acting synthetic component and clinically-proven safe natural component may define a new concept in empowering women to control their fertility and reproductive health.
  • Single dose treatment of trichomoniasis. [Randomized Controlled Trial]
    J Int Med Res. 1982; 10(2):129-30.Gabriel G, Robertson E, Thin RN
  • Oral treatment for trichomonas vaginalis infection is now well established. In a previous paper, we established the value of a high single dose regimen of metronidazole for this condition by demonstrating its efficacy in a double-blind controlled study. Tinidazole is another accepted trichomonacide. By means of a single-blind controlled trial, we demonstrate that a 2 g single dose of tinidazole i…
  • [Mutagenicity of twelve imidazole derivatives with trichomonacide activity]. [Journal Article]
    Boll Soc Ital Biol Sper. 1981 Apr 15; 57(7):805-9.Belisario MA, Quinto I, De Lorenzo F
  • The mutagenic action of twelve imidazole derivatives was investigated by Salmonella/microsome assay. All of them were mutagenic on TA 100 without metabolic activation. No direct relationship between antitrichomonad action in vitro and mutagenicity was established. As the compound XII showed much less mutagenic activity compared to the other imidazoles, we propose to perform more mutagenic studies…
  • In vitro sensitivity of Trichomonas vaginalis and Candida albicans to chemotherapeutic agents. [Journal Article]
    Acta Pathol Microbiol Scand B. 1978 Jun; 86B(3):155-8.Lövgren T, Salmela I
  • Strains of fresh clinical isolates of Trichomonas vaginalis and Candida albicans have been tested in vitro for their sensitivity to eight drugs used in the therapy of monilial and trichomonal vaginitis. Three of the chemotherapeutic agents, chlorchinaldol, clotrimazole and broxyquinoline were effective against both organisms. Tinidazole and metronidazole were active against T. vaginalis. The stra…
  • [Amoebecide and trichomonacide activities of secnidazole in the laboratory]. [Journal Article]
    Bull Soc Pathol Exot Filiales. 1976 Jul-Aug; 69(4):309-19.Benazet F, Guillaume L
  • A study of the experimental chemotherapeutic activity of secnidazole as compared to metronidazole is presented, including a summary of toxicity, metabolism, pharmacokinetic studies and preliminary results from clinical trials. Secnidazole is about twice as active as metronidazole against experimental amebiasis, equiactive against trichomoniasis, and possesses low toxicity. After oral administrati…
  • Laboratory studies with the systemic trichomonacide, metronidazole. [Journal Article]
    J Clin Pathol. 1961 Jul; 14:431-5.JENNISON RF, STENTON P, WATT L
  • Laboratory studies with the trichomonacidal agent, metronidazole, show that 66 strains of T. vaginalis were killed in three days by concentrations of 0.0625 mug./ml. to 1 mug./ml. Estimations of serum and urine levels in nine volunteers, the serum levels in 31 women, and the urine levels in 33 women show that metronidazole is rapidly absorbed and excreted in high concentration in the urine. Devel…
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