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8,301 results
  • Genital Micro-Organisms in Pregnancy. [Review]
    Front Public Health. 2020; 8:225.Bagga R, Arora P
  • The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often low virulent infectious states lead to chronic inflammatory states and maybe associated with adverse …
  • Trichomonas vaginalis NTPDase inhibited by lycorine modulates the parasite-neutrophil interaction. [Journal Article]
    Parasitol Res. 2020 Jun 11 [Online ahead of print]Petró-Silveira B, Rigo GV, … Tasca T
  • Lycorine is an Amaryllidaceae alkaloid that presents anti-Trichomonas vaginalis activity. T. vaginalis causes trichomoniasis, the most common non-viral sexually transmitted infection. The modulation of T. vaginalis purinergic signaling through the ectonucleotidases, nucleoside triphosphate diphosphohydrolase (NTPDase), and ecto-5'-nucleotidase represents new targets for combating the parasite. Wi…
  • Mycoplasma genitalium and Trichomonas vaginalis: addressing disparities and promoting public health control of two emerging sexually transmitted infections. [Journal Article]
    Curr Opin Pediatr. 2020 Jun 08 [Online ahead of print]Korich F, Reddy NG, Trent M
  • CONCLUSIONS: M. genitalium and T. vaginalis infections disproportionately affect sexual and racial/ethnic minorities and those facing socioeconomic disparities. The availability of nucleic acid amplification test testing has facilitated accurate diagnosis of both disorders. Safe and efficacious treatments are available for treatment of both disorders. Integrating macrolide resistance testing into treatment algorithms for M. genitalium and dual antibiotic therapy may prove a useful strategy for future US-based guidance. Public health reporting and increased public awareness campaigns are key next steps to addressing the observed reproductive health disparities.
  • Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis. [Journal Article]
    J Enzyme Inhib Med Chem. 2020 Dec; 35(1):1292-1299.Urbański LJ, Di Fiore A, … Parkkila S
  • We report the biochemical and structural characterisation of a beta-carbonic anhydrase (β-CA) from Trichomonas vaginalis, a unicellular parasite responsible for one of the world's leading sexually transmitted infections, trichomoniasis. CAs are ubiquitous metalloenzymes belonging to eight evolutionarily divergent groups (α, β, γ, δ, ζ, η, θ, and ι); humans express only α-CAs, whereas many clinica…
  • Adenine DNA methylation, 3D genome organization, and gene expression in the parasite Trichomonas vaginalis. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 Jun 09; 117(23):13033-13043.Lizarraga A, O'Brown ZK, … de Miguel N
  • Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract causing infections that range from asymptomatic to highly inflammatory. Recent works have highlighted the importance of histone modifications in the regulation of transcription and parasite pathogenesis. However, the nature of DNA methylation in the parasite remains unexplored. Using a combin…
  • Impact of Symbiosis Between Trichomonas vaginalis and Mycoplasma hominis on Vaginal Dysbiosis: A Mini Review. [Review]
    Front Cell Infect Microbiol. 2020; 10:179.Margarita V, Fiori PL, Rappelli P
  • The protozoon Trichomonas vaginalis is responsible for trichomoniasis, a common sexually transmitted infection associated with an increased risk of HIV infection and adverse pregnancy outcomes. The protozoon has the surprising ability to establish a symbiotic relationship with other microorganisms. In fact, most T.vaginalis isolates intracellularly host the vaginal bacterium Mycoplasma hominis an…
  • Adolescent Trichomonas vaginalis in a High-burdened Region of the Southern United States. [Journal Article]
    Sex Transm Dis. 2020 Jul; 47(7):499-502.Nolan MS, Lynn MK, … Kelly D
  • CONCLUSIONS: We identified a disproportionally high burden of T. vaginalis infection, with an alarmingly high rate of triple infections, among a population of suspected high-risk adolescents. Our results indicate the need to clarify infection prevalence, develop pediatrician-focused education campaigns, and elucidate potentially modifiable risk factors for these high-risk patients.
  • In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis. [Journal Article]
    Korean J Parasitol. 2020 Apr; 58(2):135-145.Elizondo-Luevano JH, Verde-Star J, … Chávez-Montes A
  • Infections caused by Trichomonas vaginalis in humans are one of the main public health problems caused by sexually transmitted diseases. Objective of this study was to evaluate potential biological activity of the medicinal plant Argemone mexicana (Mexican poppy) on T. vaginalis. Methanolic extracts of the stems and leaves of A. mexicana, and different fractions were prepared with solvents of dif…
  • Assessment of STI screening in Romania using a multiplex PCR technique. [Journal Article]
    J Infect Dev Ctries. 2020 Apr 30; 14(4):341-348.Grad AI, Vica ML, … Matei HV
  • CONCLUSIONS: The results suggest that multiplex PCR meets all the prerequisites for a screening method, allowing the use of multiple specimens and enabling simultaneous detection of multiple pathogens in a short period of time. STI identification via multiplex PCR proved to be an effective method for quantifying their frequency in Romania.
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