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286 results
  • A Mouse Model of Trichophyton Inflammation Based on Trichophytin-induced Contact Hypersensitivity. [Journal Article]
    Med Mycol J 2019; 60(3):65-70Nakamura T, Yoshida N, … Mochizuki T
  • The prevalence of Trichophyton-induced superficial skin mycosis is very high among human patients. Dermatophytes generally infect the epidermis, especially the stratum corneum, forming scales, hyperkeratosis, and vesicles. The important roles played by the immune system in Trichophyton infection are detection of fungal invasion and elimination of fungi.These immune mechanisms are presumed to invo…
  • Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. [Review]
    Indian Dermatol Online J 2016 Mar-Apr; 7(2):77-86Sahoo AK, Mahajan R
  • The prevalence of superficial mycotic infection worldwide is 20-25% of which dermatophytes are the most common agents. Recent developments in understanding the pathophysiology of dermatophytosis have confirmed the central role of cell-mediated immunity in countering these infections. Hence, a lack of delayed hypersensitivity reaction in presence of a positive immediate hypersensitivity (IH) respo…
  • Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-1. [Journal Article]
    Exp Dermatol 2016; 25(4):299-304Nakamura T, Nishibu A, … Mochizuki T
  • Trichophyton infection is highly prevalent and tends to be recurrent. Therefore, it is important to develop new therapeutic agents. Previously, we established a mouse model of Trichophyton-induced contact hypersensitivity (CHS) and demonstrated that dectin-1 was involved in inflammation induced by trichophytin, the Trichophyton antigen. Here, we used that model to investigate glycyrrhetinic acid …
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