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5,138 results
  • Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma. [Journal Article]
    Cancers (Basel) 2019; 11(12)Huang C, Lan W, … Santofimia-Castaño P
  • Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with almost no curative chemotherapeutic treatment. Besides the development of new compounds, repurposing of approved drugs to treat cancer, alone or in combination, has become an attractive strategy, showing many therapeutic and economic advantages. However, it is necessary to improve our knowledge about the mechanism …
  • Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. [Review]
    Cells 2019; 8(11)Santofimia-Castaño P, Xia Y, … Iovanna J
  • Cancer cells activate stress-response mechanisms to adapt themselves to a variety of stressful conditions. Among these protective mechanisms, those controlled by the stress-induced nuclear protein 1 (NUPR1) belong to the most conserved ones. NUPR1 is an 82-residue-long, monomeric, basic and intrinsically disordered protein (IDP), which was found to be invariably overexpressed in some, if not all,…
  • Computational Biology: Toward Early Detection of Pancreatic Cancer. [Journal Article]
    Crit Rev Oncog 2019; 24(2):191-198Gupta MK, Sarojamma V, … Vadde R
  • Pancreatic cancer is the eleventh most common cancer type and the seventh leading cause of cancer mortality globally. Although chemotherapy is widely employed in the treatment of any cancer type, the response rate in pancreatic cancer is very low. Hence, new and effective techniques in the treatment of pancreatic cancer are needed. Recent advances in molecular profiling as well as high-throughput…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Antipsychotic Agents [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Psychotic disorders include schizophrenia, the manic phase of manic-depressive illness (bipolar illness), acute psychosis and other conditions marked by acute, severe agitation. The antipsychotic medications are invaluable adjuncts to the treatment of psychosis and bipolar illness and have revolutionized management of these conditions. The antipsychotic agents in clinical use include the phenothi…
  • Antipsychotic Drug Trifluoperazine Suppresses Colorectal Cancer by Inducing G0/G1 Arrest and Apoptosis. [Journal Article]
    Front Pharmacol 2019; 10:1029Xia Y, Jia C, … Ye T
  • Repurposing existing drugs for cancer treatment is an effective strategy. An approved antipsychotic drug, trifluoperazine (TFP), has been reported to have potential anticancer effects against several cancer types. Here, we investigated the effect and molecular mechanism of TFP in colorectal cancer (CRC). In vitro studies showed that TFP induced G0/G1 cell cycle arrest to dramatically inhibit CRC …
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