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(trifluoperazine hydrochloride)
5,126 results
  • The effect of anti-emetic drugs on rat embryonic heart activity. [Journal Article]
    Reprod Toxicol 2019; 87:140-145Ritchie HE, Huss IB, Webster WS
  • Nausea and vomiting of pregnancy (NVP) is the most common medical complaint during pregnancy affecting up to 70% of pregnant women worldwide. Some antiemetic medications (AEM) (droperidol, domperidone, granisetron, metoclopramide and trifluoperazine) used to treat NVP have the unwanted side effect of hERG blockade. The hERG potassium channel is essential for normal heart rhythm in both the adult …
  • Trifluoperazine as an alternative strategy for the inhibition of tumor growth of colorectal cancer. [Journal Article]
    J Cell Biochem 2019; 120(9):15756-15765Qian K, Sun L, … Fang X
  • The development of cancer in patients with schizophrenia is affected by genetic and environmental factors and antipsychotic medication. Several studies found that schizophrenia was associated with decreased risk of some cancers, and the neuroleptic medication might help to reduce the risk of colorectal cancer (CRC). Phenothiazine drugs including trifluoperazine (TFP) are widely used antipsychotic…
  • Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. [Journal Article]
    J Clin Invest 2019; 129(6):2500-2513Santofimia-Castaño P, Xia Y, … Iovanna J
  • Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of their prevalence in various diseases including cancer. Drug development targeting IDPs is challenging because they have dynamical structure features and conventional drug design is not applicable. NUPR1 is an IDP playing an important role in pancreatic cancer. We previously reported that Trifluoperazine …
  • Targeting Type IV pili as an antivirulence strategy against invasive meningococcal disease. [Journal Article]
    Nat Microbiol 2019; 4(6):972-984Denis K, Le Bris M, … Bourdoulous S
  • Bacterial virulence factors are attractive targets for the development of therapeutics. Type IV pili, which are associated with a remarkable array of properties including motility, the interaction between bacteria and attachment to biotic and abiotic surfaces, represent particularly appealing virulence factor targets. Type IV pili are present in numerous bacterial species and are critical for the…
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