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(trihexyphenidyl hydrochloride)
1,189 results
  • Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2. [Journal Article]
    Pharmacol Res Perspect 2019; 7(4):e00504Oranje P, Gouka R, … van Westen GJP
  • Selective analogs of the natural glycoside phloridzin are marketed drugs that reduce hyperglycemia in diabetes by inhibiting the active sodium glucose cotransporter SGLT2 in the kidneys. In addition, intestinal SGLT1 is now recognized as a target for glycemic control. To expand available type 2 diabetes remedies, we aimed to find novel SGLT1 inhibitors beyond the chemical space of glycosides. We …
  • Pharmacological management of abnormal tone and movement in cerebral palsy. [Journal Article]
    Arch Dis Child 2019; 104(8):775-780Lumsden DE, Crowe B, … Cadwgan J
  • CONCLUSIONS: CYP with CP frequently present with a complex movement phenotype and comorbid epilepsy. They have multiple therapy, medical and surgical management regimens. Future trials of therapeutic, pharmacological or surgical interventions in this population must adequately encompass this complexity in order to be translatable to clinical practice.
  • Some Possibilities to Study New Prophylactics against Nerve Agents. [Review]
    Mini Rev Med Chem 2019; 19(12):970-979Bajgar J, Kassa J, … Kuca K
  • Nerve agents belong to the most dangerous chemical warfare agents and can be/were misused by terrorists. Effective prophylaxis and treatment is necessary to diminish their effect. General principles of prophylaxis are summarized (protection against acetylcholinesterase inhibition, detoxification, treatment "in advance" and use of different drugs). They are based on the knowledge of mechanism of a…
  • GeneReviews®: VPS13D Movement Disorder [BOOK]
    University of Washington, Seattle: Seattle (WA)Adam MP, Ardinger HH, … Amemiya AMeijer IABOOK
  • VPS13D movement disorder is a hyperkinetic movement disorder (dystonia, chorea, and/or ataxia) of variable age of onset that can be associated with developmental delay. Onset ranges from birth to adulthood. Individuals can present in childhood with motor delays and gait instability. Cognitive impairment ranging from mild intellectual disability to developmental delay has been reported, and severa…
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