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31,009 results
  • Thyroid hormones as potential prognostic factors in sepsis. [Journal Article]
    Anaesthesiol Intensive Ther 2019Foks M, Dudek A, … Szczeklik W
  • CONCLUSIONS: Thyroid hormone levels were significantly lower among patients who died during ICU stay. The results of the presented study suggest that fT3 and fT4 levels may be taken into consideration as potential new prognostic factors in sepsis.
    Endocr Pract 2019Sue LY, Kim JE, … Leung AM
  • CONCLUSIONS: Although national societal guidelines recommend against ordering serum T3 concentrations while monitoring patients with hypothyroidism managed with levothyroxine, these laboratory tests are frequently ordered. Development of a triggered alert in the health record may reduce inappropriate monitoring practices, decrease costs, and improve utilization of limited healthcare resources for this common clinical condition. Abbreviations T3 = triiodothyronine; BPA = best practice alert; ATA = American Thyroid Association; U.S. = United States; TSH = thyroid stimulating hormone.
  • Wnt3a downregulates thyroid hormone-induced osteocalcin expression in osteoblasts. [Journal Article]
    Exp Ther Med 2019; 18(3):1921-1927Fujita K, Otsuka T, … Tokuda H
  • Wnt3a is a crucial modulator of bone metabolism through the canonical Wnt/β-catenin signaling pathway in bone-forming osteoblasts. We previously reported that the expression of osteocalcin is stimulated by triiodothyronine (T3) at least in part through the activation of p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase in osteoblast-like MC3T3-E1 cells. In the present study, w…
  • A Systematic Review and Meta-Analysis of Patient Preferences for Combination Thyroid Hormone Treatment for Hypothyroidism. [Systematic Review]
    Front Endocrinol (Lausanne) 2019; 10:477Akirov A, Fazelzad R, … Sawka AM
  • CONCLUSIONS: In conclusion, in RCTs in which patients and investigators were blinded to treatment allocation, approximately half of participants reported preferring combination L-T3 and L-T4 therapy compared to L-T4 alone; this finding was not distinguishable from chance. An observed potential positive L-T3 dose effect on treatment preference deserves further study, with careful consideration of thyroid biochemical indices and patient reported outcomes.
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