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31,463 results
  • Female Athlete Triad Coalition Cumulative Risk Assessment Tool: Proposed alternative scoring strategies. [Journal Article]
    Appl Physiol Nutr Metab. 2020 Jun 05 [Online ahead of print]Koltun KJ, Williams NI, De Souza MJ
  • We identified alternative scoring strategies for the Female Athlete Triad Coalition cumulative risk assessment (CRA) tool to be utilized when particular risk factors (bone mineral density (BMD), oligomenorrhea/amenorrhea) cannot be determined, objectively defined dietary restriction, and explored proxy measures of energy deficiency. This cross-sectional investigation of exercising women (n=166) u…
  • Identification of resistance to exogenous thyroxine in humans. [Journal Article]
    Thyroid. 2020 Jun 05 [Online ahead of print]Lacámara N, Lecumberri B, … Moreno JC
  • CONCLUSIONS: Human RETH is characterized by iatrogenic thyrotoxicosis and elevated TSH/fT4 ratio. In the euthyroid/hyperthyrotropinemic state, it is confirmed by decreased T3/T4 and T3/rT3 ratios, and elevated rT3/T4 ratio. This phenotype may guide clinicians to consider combined T4+T3 therapy in a targeted fashion. The absence of germline DIO2 mutations suggests that aberrant posttranslational D2 modifications in pituitary/hypothalamus or defects in other genes regulating the T4 to T3 conversion pathway could be involved in RETH.
  • Fetal goiter identified in a pregnant woman with triiodothyronine-predominant graves' disease: a case report. [Journal Article]
    BMC Pregnancy Childbirth. 2020 Jun 03; 20(1):344.Fujishima A, Sato A, … Terada Y
  • CONCLUSIONS: The recommended perinatal management of Graves' disease is to adjust free T4 within a range from the upper limit of normal to a slightly elevated level in order to maintain the thyroid function of the fetus. However, in T3-predominant cases, free T4 levels may drop during the long-term course of the pregnancy owing to attempts to control the mother's symptoms of thyrotoxicosis. Little is known about the perinatal management and appropriate therapeutic strategy for T3-predominant cases and fetal goiter. Therefore, further investigation is necessary.
  • Relationship of thyroid dysfunction with cardiovascular diseases: updated review on heart failure progression. [Review]
    Hormones (Athens). 2020 Jun 02 [Online ahead of print]Abdel-Moneim A, Gaber AM, … Allam G
  • Heart disease remains the leading cause of death globally. Heart failure (HF) is a clinical syndrome that results from impairment of the ability of the ventricle to fill with or eject blood. Over the past two decades, accumulated evidence has revealed the contribution of thyroid hormones to cardiovascular (CV) events, exerting their action through genomic and non-genomic pathways within the cardi…
  • Pharmacodynamic Response to Anti-thyroid Drugs in Graves' Hyperthyroidism. [Journal Article]
    Front Endocrinol (Lausanne). 2020; 11:286.Abbara A, Clarke SA, … Dhillo WS
  • Objective: Graves' disease is the commonest cause of hyperthyroidism in populations with sufficient dietary iodine intake. Anti-thyroid drugs (ATD) are often used as the initial treatment for Graves' hyperthyroidism, however there is a paucity of data relating the dose of ATD therapy to the effect on thyroid hormone levels, increasing the risk of both over- and under-treatment. We aimed to deter…
  • Sonic Hedgehog and Triiodothyronine Pathway Interact in Mouse Embryonic Neural Stem Cells. [Journal Article]
    Int J Mol Sci. 2020 May 23; 21(10)Ostasov P, Tuma J, … Babuska V
  • Neural stem cells are fundamental to development of the central nervous system (CNS)-as well as its plasticity and regeneration-and represent a potential tool for neuro transplantation therapy and research. This study is focused on examination of the proliferation dynamic and fate of embryonic neural stem cells (eNSCs) under differentiating conditions. In this work, we analyzed eNSCs differentiat…
  • The many faces of thyroxine. [Journal Article]
    AIMS Neurosci. 2020; 7(1):17-29.Dratman MB, Martin JV
  • Hönes et al. have recently shown that in vivo interference with the apparatus of the nuclear receptor-mediated, gene-driven mechanism of triiodothyronine (T3) actions fails to eliminate all actions of T3. However, the investigators conducting that study provided little information regarding the mechanisms that might be responsible for conferring those implied gene-independent effects. Dratman has…
  • gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism. [Journal Article]
    Int J Endocrinol. 2020; 2020:3161730.Ma X, Wang F, … Zhou X
  • CONCLUSIONS: Our work demonstrated that the levels of gp91phox, a novel biomarker for measuring the oxidative stress, were significantly elevated in the patients with SH. And LDL-C and TSH were both independent predictors of gp91phox. Abbreviations. BMI : Body mass index; TC : Total cholesterol; LDL-C : Low-density lipoprotein cholesterol; HDL-C : High-density lipoprotein cholesterol; TG : Triglyceride; FBG : Fasting blood glucose; FT3 : Free triiodothyronine; FT4 : Free thyroxine; TSH: Thyroid stimulating hormone; SBP : Systolic blood pressure; DBP : Diastolic blood pressure; SD : Standard deviation; LSD: Least significant difference.
  • Subacute Thyroiditis After Sars-COV-2 Infection. [Journal Article]
    J Clin Endocrinol Metab. 2020 07 01; 105(7)Brancatella A, Ricci D, … Latrofa F
  • CONCLUSIONS: We report the first case of SAT after a SARS-CoV-2 infection. We alert clinicians to additional and unreported clinical manifestations associated with COVID-19.
  • Diagnosis and treatment of low T3 syndrome in neurocritical patients. [Journal Article]
    J Clin Pharm Ther. 2020 May 14 [Online ahead of print]Chen Y, Chang J, … Wei J
  • CONCLUSIONS: The neurocritical events in our cohort included post-operative complications (n = 18), traumatic brain injury (n = 8) and spontaneous intracerebral haemorrhage (n = 6). Mean GCS score in the cohort was 6.41 (6.44 ± 3.14 in HRT group vs 6.36 ± 2.06 in non-HRT group). A total of 15/32 (46.87%) deaths were recorded (7 in the HRT group, 8 in the non-HRT group). In the HRT group, 15 patients underwent repeat thyroid function tests after completion of HRT; the low T3 situation was corrected in only 5/15 (33.3%) patients. Overall survival was significantly shorter in the non-HRT group than in the HRT group (16.45 months vs 47.47 months; P = .034). In univariate regression analysis, the HRT group has the lower mortality risk than the non-HRT group (HR = 0.301, 95% Cl: 0.094-0.964; P = .043). However, multivariate regression analysis showed no significant difference in mortality risk between the two groups (HR = 0.340 95% CI: 0.099-1.172; P = .087). There was no significant difference in effects of HRT on the short- and long-term neurological function between the groups.Low T3 syndrome may influence the prognosis of neurocritical patients, attention should be paid to the changes in serum T3 levels during treatment. Although it is unclear to what extent HRT can improve the short or long-term outcomes of neurological function, it can significantly improve the survival rates of neurocritical patients.
  • Thyroid hormones and the mechanisms of adaptation to cold. [Review]
    Hormones (Athens). 2020 May 12 [Online ahead of print]Tsibulnikov S, Maslov L, … Oeltgen P
  • The thyroid gland plays a crucial role in the regulation of metabolism, oxygen consumption, and the release of energy in the form of heat to maintain the body. Even at rest, these processes are sensitive to changes in thyroid function. This means that along with the adrenergic system, thyroid function determines the organism's ability to adapt to cold. Cold adaptation causes deiodination of thyro…
  • Neurotoxicity and related mechanisms of flame retardant TCEP exposure in mice. [Journal Article]
    Toxicol Mech Methods. 2020 May 12 [Online ahead of print]Wang C, Chen Z, … Song J
  • Objective: To explore the neurotoxicity and mechanism of tris(2-chloroethyl) phosphate (TCEP) exposure in mice. Methods: Total 30 adult Kunming mice were randomly divided into normal control group (0 mg/kg·d), low-dose TCEP group (10 mg/kg·d), and high-dose TCEP group (100 mg/kg·d), and administered continuously by gavage for 30 days. Results: Compared with the control group, the water intake …
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