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233 results
  • Trimebutine: a state-of-the-art review. [Journal Article]
    Minerva Gastroenterol Dietol 2019; 65(3):229-238Salvioli B
  • Trimebutine maleate has been used extensively, since the late 1960's, for the treatment of functional gastrointestinal disorders, including irritable bowel syndrome (IBS). It is usually linked to the antispasmodic class of agents, but its properties make trimebutine an unmatched and multi-tasking compound. The efficacy on relieving abdominal pain has been demonstrated in various clinical studies …
  • Trimebutine Promotes Glioma Cell Apoptosis as a Potential Anti-tumor Agent. [Journal Article]
    Front Pharmacol 2018; 9:664Fan YP, Liu P, … Pan HC
  • Gliomas are the most common primary brain tumors with a usually fatal malignancy. They are associated with a poor prognosis although multiple therapeutic options have been available. Trimebutine is one of the prokinetic agents and it has been mainly used for treatment of disorders of the gastrointestinal (GI) tract such as irritable bowel syndrome. However, its effects on glioma cells remain unkn…
  • Inhibitory Effects of Gastrointestinal Drugs on CYP Activities in Human Liver Microsomes. [Journal Article]
    Biol Pharm Bull 2017; 40(10):1654-1660Iwase M, Nishimura Y, … Kiuchi Y
  • OTC drugs have an important role in self-medication. However, the pharmacokinetic properties of some OTC drugs have not been fully investigated and reports concerning their drug interactions are insufficient. Several gastrointestinal drugs are available as OTC drugs. Because of their pharmacological properties, these drugs are often used concomitantly with other drugs. Therefore, it is important …
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