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399 results
  • Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation. [Journal Article]
    Eur J Pharmacol 2019; 847:42-52Díaz Nebreda A, Zappia CD, … Shayo C
  • Histamine [2-(4-Imidazolyl)-ethylamine] modulates different biological processes, through histamine H1 and H2 receptors, and their respective blockers are widely used in treating allergic and gastric acid-related disorders. Histamine H1 and H2 receptor crossdesensitization and cointernalization induced by its agonists have been previously described. In this study, we show how this crosstalk deter…
  • Drugs and Lactation Database (LactMed): Triprolidine [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • Small, occasional doses of triprolidine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
  • Effect of premedications in a murine model of asparaginase hypersensitivity. [Journal Article]
    J Pharmacol Exp Ther 2015; 352(3):541-51Fernandez CA, Smith C, … Relling MV
  • A murine model was developed that recapitulates key features of clinical hypersensitivity to Escherichia coli asparaginase. Sensitized mice developed high levels of anti-asparaginase IgG antibodies and had immediate hypersensitivity reactions to asparaginase upon challenge. Sensitized mice had complete inhibition of plasma asparaginase activity (P = 4.2 × 10(-13)) and elevated levels of mouse mas…
  • Effects of antihistamines on the function of human α7-nicotinic acetylcholine receptors. [Journal Article]
    Eur J Pharmacol 2015; 746:308-16Sadek B, Khanian SS, … Oz M
  • Effects of the histamine H₁ receptor (H1R) antagonists (antihistamines), promethazine (PMZ), orphenadrine (ORP), chlorpheniramine (CLP), pyrilamine (PYR), diphenhydramine (DPH), citerizine (CTZ), and triprolidine (TRP) on the functional properties of the cloned α7 subunit of the human nicotinic acetylcholine receptor expressed in Xenopus oocytes were investigated. Antihistamines inhibited the α7-…
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