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Unbound Medicine.
(tritiated thymidine)
4,584 results
  • CellTrace Violet™ inhibits equine lymphocyte proliferation. [Journal Article]
    Vet Immunol Immunopathol. 2020 May; 223:110037.J Lacy K, Parlane NA, … McIlwraith CW
  • CellTrace Violet™ is a commonly used fluorescent dye used with flow cytometry to identify cell proliferation. Activated equine lymphocytes were examined using flow cytometry, microscopy and tritiated thymidine proliferation assays. CellTrace Violet™ was incorporated into the equine lymphocytes effectively. Equine lymphocytes proliferated when activated with pokeweed mitogen, but did not prolifera…
  • Assessing the Impact of Phytochemicals on Immune Checkpoints: Implications for Cancer Immunotherapy. [Journal Article]
    Methods Mol Biol. 2020; 2111:161-173.Power Coombs MR, Hoskin DW
  • Phytochemicals are the basis for many anticancer drugs currently in clinical use, as well as a potential source of future cancer treatments. Some phytochemicals have been found to modify the expression of checkpoint inhibitors of the immune response, as well as kill cancer cells. Cancer cells, in turn, may evade detection by the immune system by expressing molecules such as programmed death ligan…
  • Inhibition of collagen production delays malignant mesothelioma tumor growth in a murine model. [Journal Article]
    Biochem Biophys Res Commun. 2019 03 05; 510(2):198-204.Abayasiriwardana KS, Wood MK, … Mutsaers SE
  • Malignant mesothelioma is an aggressive fibrous tumor, predominantly of the pleura, with a very poor prognosis. Cell-matrix interactions are recognized important determinants of tumor growth and invasiveness but the role of the extracellular matrix in mesothelioma is unknown. Mesothelioma cells synthesize collagen as well as transforming growth factor-beta (TGF-β), a key regulator of collagen pro…
  • Role of IL-35 in sublingual allergen immunotherapy. [Journal Article]
    J Allergy Clin Immunol. 2019 Mar; 143(3):1131-1142.e4.Shamji MH, Layhadi JA, … Durham SR
  • CONCLUSIONS: IL-35 and iTR35 cells are potential novel immune regulators induced by SLIT. The clinical relevance of SLIT can be underscored by restoration of protective iTR35 cells.
  • Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment. [Journal Article]
    Methods Mol Biol. 2018; 1803:101-116.Lehmann DM
  • Allergic contact dermatitis (ACD) continues to be an occupational and environmental health issue. Consequently, there is a need to employ predictive tests to reduce the incidence of skin sensitization leading to clinical manifestations of ACD. For more than a decade, the murine local lymph node assay (LLNA) has been the method of choice for the identification of skin sensitizers. While the origin…
  • Tritium internal dose estimation from measurements with liquid scintillators. [Journal Article]
    Appl Radiat Isot. 2018 Jul; 137:18-22.Pántya A, Dálnoki Á, … Pázmándi T
  • Tritium may exist in several chemical and physical forms in workplaces, common occurrences are in vapor or liquid form (as tritiated water) and in organic form (e.g. thymidine) which can get into the body by inhalation or by ingestion. For internal dose assessment it is usually assumed that urine samples for tritium analysis are obtained after the tritium concentration inside the body has reached…
  • Identifying Quiescent Stem Cells in Hair Follicles. [Journal Article]
    Methods Mol Biol. 2018; 1686:137-147.Rodriguez CN, Nguyen H
  • Hair follicle stem cells (HFSCs) are noted for their relative quiescence and therefore can be distinguished from other cells by their differential history of cell division. Replicating cells can be labeled by pulsing the animals repeatedly with 5-bromo-2'-deoxyuridine (BrdU) or tritiated thymidine ([3H]TdR), thymidine analogs that get incorporated into DNA during DNA synthesis. Because dividing c…
  • Spermatogenesis in a neotropical marsupial species, Philander frenatus (Olfers, 1818). [Journal Article]
    Anim Reprod Sci. 2017 Sep; 184:102-109.Figueiredo AFA, Cordeiro DA, … Costa GMJ
  • Despite the singular morphology of the male genital system and the different reproductive strategies of marsupials, little emphasis has been given to the testis morphology and spermatogenic kinetics in this mammalian order. The present study aimed to investigate the testis function and the duration of spermatogenesis in the southeastern four-eyed opossum, Philander frenatus. Testes of six adult m…
  • Synthesis, cytotoxicity and antifungal activity of 5-nitro-thiophene-thiosemicarbazones derivatives. [Journal Article]
    Chem Biol Interact. 2017 Jun 25; Araújo Neto LN, do Carmo Alves de Lima M, … Mendonça-Junior FJB
  • In the present work, twelve N-substituted 2-(5-nitro-thiophene)-thiosemicarbazones derivatives (L1-12) were synthesized, characterized and their in vitro cytotoxic and antifungal activities were evaluated against Candida sp. and Cryptococcus neoformans. The probable mechanisms of action have been investigated by sorbitol and ergosterol assays. Additionally, ultrastructural study by Scanning Elect…
  • Quantification of epithelial cell proliferation, cell dynamics, and cell kinetics in vivo. [Review]
    Wiley Interdiscip Rev Dev Biol. 2017 07; 6(4)Goodlad RA
  • The measurement of cell proliferation in vivo is usually carried out by the examination of static measures. These comprise the mitotic index or labeling indices using incorporation of DNA synthesis markers such as bromodeoxyuridine or tritiated thymidine, or intrinsic markers, such as Ki67 and proliferative cell nuclear antigen (PCNA). But static measures only provide a 'snapshot' of cell prolife…
  • Quantification of Viral and Prokaryotic Production Rates in Benthic Ecosystems: A Methods Comparison. [Journal Article]
    Front Microbiol. 2016; 7:1501.Rastelli E, Dell'Anno A, … Danovaro R
  • Viruses profoundly influence benthic marine ecosystems by infecting and subsequently killing their prokaryotic hosts, thereby impacting the cycling of carbon and nutrients. Previously conducted studies, based on different methodologies, have provided widely differing estimates of the relevance of viruses on benthic prokaryotes. There has been no attempt so far to compare these independent approac…
  • Endocrine and social regulation of adult neurogenesis in songbirds. [Review]
    Front Neuroendocrinol. 2016 04; 41:3-22.Balthazart J, Ball GF
  • The identification of pronounced seasonal changes in the volume of avian song control nuclei stimulated the discovery of adult neurogenesis in songbirds as well as renewed studies in mammals including humans. Neurogenesis in songbirds is modulated by testosterone and other factors such as photoperiod, singing activity and social environment. Adult neurogenesis has been widely studied by labeling,…
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