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23,955 results
  • [Development of Medicines for Infectious Diseases -Malaria]. [Journal Article]
    Yakugaku Zasshi. 2020; 140(7):887-894.Kita K
  • In developed countries, it is said that "threats of infectious diseases are already thought as things of the past". However, as you can see in the case of Ebola hemorrhagic fever that occurred in West Africa, this is a big mistake. Among infectious diseases, only smallpox has been successfully eradicated worldwide. In addition to the three major infectious diseases of HIV/AIDS, tuberculosis, and …
  • Highly Localized Enrichment of Trypanosoma brucei Parasites Using Dielectrophoresis. [Journal Article]
    Micromachines (Basel). 2020 Jun 26; 11(6)Keck D, Stuart C, … Martinez-Duarte R
  • Human African trypanosomiasis (HAT), also known as sleeping sickness, is a vector-borne neglected tropical disease endemic to rural sub-Saharan Africa. Current methods of early detection in the affected rural communities generally begin with general screening using the card agglutination test for trypanosomiasis (CATT), a serological test. However, the gold standard for confirmation of trypanosom…
  • Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites. [Review]
    Microorganisms. 2020 Jun 24; 8(6)Van den Kerkhof M, Sterckx YG, … Caljon G
  • Kinetoplastids are the causative agents of leishmaniasis, human African trypanosomiasis, and American trypanosomiasis. They are responsible for high mortality and morbidity in (sub)tropical regions. Adequate treatment options are limited and have several drawbacks, such as toxicity, need for parenteral administration, and occurrence of treatment failure and drug resistance. Therefore, there is an…
  • To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host. [Review]
    Front Immunol. 2020; 11:1250.Alfituri OA, Quintana JF, … Capewell P
  • African trypanosomes are single-celled extracellular protozoan parasites transmitted by tsetse fly vectors across sub-Saharan Africa, causing serious disease in both humans and animals. Mammalian infections begin when the tsetse fly penetrates the skin in order to take a blood meal, depositing trypanosomes into the dermal layer. Similarly, onward transmission occurs when differentiated and insect…
  • Trypanosome infections in naturally infected horses and donkeys of three active sleeping sickness foci in the south of Chad. [Journal Article]
    Parasit Vectors. 2020 Jun 23; 13(1):323.Vourchakbé J, Tiofack AAZ, … Simo G
  • CONCLUSIONS: This study revealed several trypanosome species and subspecies in donkeys and horses, highlighting the existence of AAT in HAT foci in Chad. The identification of T. b. gambiense in donkeys and horses suggests considering these animals as potential reservoir for HAT in Chad. The presence of both human-infective and human non-infective trypanosomes species highlights the need for developing joint control strategies for HAT and AAT.
  • Ribose-5-phosphate isomerases: characteristics, structural features, and applications. [Review]
    Appl Microbiol Biotechnol. 2020 Jun 12 [Online ahead of print]Chen J, Wu H, … Mu W
  • Ribose-5-phosphate isomerase (Rpi, EC is widespread in microorganisms, animals, and plants. It has a pivotal role in the pentose phosphate pathway and responsible for catalyzing the isomerization between D-ribulose 5-phosphate and D-ribose 5-phosphate. In recent years, Rpi has received considerable attention as a multipurpose biocatalyst for production of rare sugars, including D-allose,…
  • Toosendanin relatives, trypanocidal principles from Meliae Cortex. [Journal Article]
    J Nat Med. 2020 Jun 11 [Online ahead of print]Mifundu MN, Murakami N, … Tamura S
  • Africa Trypanosomiasis remains a serious health problem, but the approved drugs for this disease are so few that novel trypanocidal compounds are demanded. In search for trypanocidal principles from medicinal plants, we found MeOH extracts of Meliae Cortex with potent activity through the screening from about 300 kinds of methanolic extract. By bioassay-guided fractionation from this extract thro…
    Acta Trop. 2020 Jun 08 [Online ahead of print]Cruz ACFG, Santos NAF, … de Melo CM
  • Shelters are places that receive certain species of domestic animals, mostly dogs and cats, that are normally abandoned. These animals are easy to handle because they are crowded and have limited movement. Dogs, due to the close relationship with humans, are considered the main domestic reservoirs in the peridomiciliary cycle of American trypanosomiasis infection in humans. Therefore, in several …
  • StatPearls: Pentamidine [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Hafiz Sumaiya S Dubai Medical College Modi Palmi V. PV L. J. Institute of Pharmacy BOOK
  • Pentamidine is a broad-spectrum anti-infective agent active against several parasitic worms, protozoa, and fungi. It has been used in the treatment of Pneumocystis jiroveci pneumonia in the immunocompromised, leishmaniasis (cutaneous and Visceral), and Human African trypanosomiasis (African Sleeping sickness). It is a relatively toxic drug and requires careful monitoring during therapy. 
  • Development of Trypanosoma everetti in Culicoides biting midges. [Journal Article]
    Acta Trop. 2020 May 28; 210:105555.Bernotienė R, Iezhova TA, … Valkiūnas G
  • Trypanosoma species (Trypanosomatida, Kinetoplastea) are almost exclusively heteroxenous flagellated parasites, which have been extensively studied as the causative agents of severe trypanosomiasis in humans and domestic animals. However, the biology of avian trypanosomes remains insufficiently known, particularly in wildlife, despite information that some species might be pathogenic and affect t…
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