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260,302 results
  • Interplay between alveolar epithelial and dendritic cells and Mycobacterium tuberculosis. [Review]
    J Leukoc Biol. 2020 Jul 03 [Online ahead of print]Rodrigues TS, Conti BJ, … Bonato VLD
  • The innate response plays a crucial role in the protection against tuberculosis development. Moreover, the initial steps that drive the host-pathogen interaction following Mycobacterium tuberculosis infection are critical for the development of adaptive immune response. As alveolar Mϕs, airway epithelial cells, and dendritic cells can sense the presence of M. tuberculosis and are the first infect…
  • How antibiotics work together: molecular mechanisms behind combination therapy. [Review]
    Curr Opin Microbiol. 2020 Jun 30; 57:31-40.Sullivan GJ, Delgado NN, … Cain AK
  • Antibiotics used in combination are an effective strategy for combatting numerous infectious diseases in clinical and veterinary settings, particularly as a last-line therapy for difficult-to-treat cases. Combination therapy can either increase or slow the rate of killing, broaden the antibiotic spectrum, reduce dosage and unwanted side-effects, and even control the emergence of resistance. The a…
  • Risk stratification and management of QuantiFERON-positive solid-organ living donors. [Journal Article]
    Curr Opin Organ Transplant. 2020 Jun 30 [Online ahead of print]Gibb J, Wong D
  • CONCLUSIONS: Living donors with an elevated risk for prior MTB exposure provide an opportunity to treat latent disease prior to organ procurement and reduce the risk of donor transmitted disease and secondary morbidity. Improved identification of these high-risk donors can reduce both the incidence of posttransplant MTB disease and the risk of allograft compromise associated with treatment of latent and active disease in posttransplant recipients.
  • Predictors of Loss to Follow-Up among Men with Tuberculosis in Puducherry and Tamil Nadu, India. [Journal Article]
    Am J Trop Med Hyg. 2020 Jul 06 [Online ahead of print]Zhou TJ, Lakshminarayanan S, … Hochberg NS
  • Identifying predictors of loss to follow-up (LTFU; treatment lapse ≥ 2 months) among people with tuberculosis (TB) may assist programmatic efforts in controlling the spread of TB. Newly diagnosed smear-positive TB patients were enrolled in the Regional Prospective Observational Research for TB study in Puducherry and Tamil Nadu, India. Treatment records were used to identify LTFU of those who wer…
  • History of Acquired Immune Deficiency Syndrome in Korea. [Review]
    Infect Chemother. 2020 Jun; 52(2):234-244.Kim JM, Kim NJ, … Chin BS
  • The first human immunodeficiency virus (HIV) infection was reported in Korea in 1985. The number of HIV-infected persons domestically increased in the 1990s showing epidemic indigenousization. Since then, the number of new infections gradually increased every year, and recently more than 1,000 newly infected cases were reported per year. A total of 12,522 infected individuals have been reported u…
  • Nanoparticle-mediated macrophage targeting-a new inhalation therapy tackling tuberculosis. [Journal Article]
    Drug Deliv Transl Res. 2020 Jul 02 [Online ahead of print]Makled S, Boraie N, Nafee N
  • Despite the potent clinical efficacy of linezolid (LNZ) against drug-resistant tuberculosis, its safety and tolerability remain of major concern. Our objective is to develop antitubercular inhalable LNZ nano-embedded microparticles. In this context, LNZ incorporated in non-structured lipid carriers (NLCs) was characterized in terms of colloidal, morphological, thermal, and release profiles. The p…
  • Retrospective analysis of 1,641 cases of classic fever of unknown origin. [Journal Article]
    Ann Transl Med. 2020 Jun; 8(11):690.Zhou G, Zhou Y, … Lv X
  • CONCLUSIONS: Infectious diseases are the principal cause of classic FUO, in which tuberculosis accounts for a large proportion. Non-infectious diseases that cause FUO are mainly connective tissue diseases and malignant tumors. Of the various causes of classic FUO, tuberculosis and lymphoma are relatively difficult to diagnose. In most cases, the causes of classic FUO can be ascertained.
  • African histoplasmosis of the penis. [Case Reports]
    Oxf Med Case Reports. 2020 Jun; 2020(6):omaa043.Darré T, Kpatcha M, … Napo-Koura G
  • African Histoplasmosis is deep mycosis caused by Histoplasma duboisii and genitourinary involvement is extremely rare. We report a case of African histoplasmosis in a 27-year-old subject with painful penis ulcer. Ulcer edge biopsy had revealed inflammatory granulomas made of epithelioid cells, lymphoplasmocytes, polynuclear eosinophils and giant multinucleated cells, with ovoid yeasts surrounded …
  • 6,6'-Aryl trehalose analogs as potential Mincle ligands. [Journal Article]
    Bioorg Med Chem. 2020 Jul 15; 28(14):115564.Rasheed OK, Ettenger G, … Ryter KT
  • 6,6'-Aryl trehalose derivatives have been synthesized with a view towards identifying novel Th-17-inducing vaccine adjuvants based on the high affinity Mincle ligand Brartemicin. The initial structure-activity relationships of these novel trehalose-based compounds were investigated. All compounds have been evaluated for their ability to engage the Mincle receptor and induce a potential pro-Th17 c…
  • mycoCSM: using graph-based signatures to identify safe potent hits against Mycobacteria. [Journal Article]
    J Chem Inf Model. 2020 Jul 02 [Online ahead of print]Pires D, Ascher DB
  • Development of new potent, safe drugs to treat Mycobacteria has proven to be challenging, with limited hit rates of initial screens restricting subsequent development efforts. Despite significant efforts and evolution of Quantitative Structure-Activity Relationship (QSAR) as well as machine learning-based models for computationally predicting molecule bioactivity, there is an unmet need for effic…
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