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(tubocurarine chloride)
6,084 results
  • Discovering Pain in Newborn Infants. [Journal Article]
    Anesthesiology 2019; 131(2):392-395Anand KJS
  • Randomised Trial of Fentanyl Anesthesia in Preterm Babies Undergoing Surgery: Effects on the Stress Response. By Anand KJ, Sippell WG, and Aynsley-Green A. Lancet 1987; 1:243-8. Reprinted with permission.In a randomised controlled trial, preterm babies undergoing ligation of a patent ductus arteriosus were given nitrous oxide and D-tubocurarine, with (n = 8) or without (n = 8) the addition of fen…
  • StatPearls: Cisatracurium [BOOK]
    StatPearls Publishing: Treasure Island (FL) Strawbridge Andrew D. AD San Antonio Uniformed Services HEC Hauser Joshua M. JM Brooke Army Medical Center BOOK
  • Cisatracurium besylate is an intermediate-acting, non-depolarizing neuromuscular blocking drug (NMBD). Cisatracurium has a benzylisoquinolinium structure and is the 1R cis-1’R cis isomer of atracurium. Metocurine and d-Tubocurarine are also in the benzylisoquinolinium class.[1] As an NMBD, it has found use as an adjunct to general anesthesia facilitating tracheal intubation and providing skeletal…
  • The Place of Erythroidines in the History of Neuromuscular Blockers. [Journal Article]
    J Anesth Hist 2019; 5(1):22-24McKenzie AG
  • Between 1938 and 1951 erythroidine derivatives were seriously considered as alternatives to curare for the provision of muscle relaxation. This has been overlooked in the published history of anaesthesia. The first publication on the paralysing effect of an extract of Erythrina americana was in 1877, but this was in a Mexican journal, which was not widely read. Sixty years later erythroidine was …
  • StatPearls: Pancuronium [BOOK]
    StatPearls Publishing: Treasure Island (FL) Das Gyan N. GN San Antonio Military Medical Center Maani Christopher V. CV US Army BOOK
  • Pancuronium bromide is a long-acting, bis-quaternary aminosteroid, non-depolarizing, neuromuscular blocking drug (NMBD) which was first synthesized in 1964 and was found to possess fewer adverse effects with regards to hemodynamic stability and histamine release as compared to the prototypical NMBD, d-tubocurarine.[1][2] After the arrival of intermediate-acting NMBDs such as vecuronium, rocuroniu…
  • Acetylcholine receptors in the equatorial region of intrafusal muscle fibres modulate mouse muscle spindle sensitivity. [Journal Article]
    J Physiol 2019; 597(7):1993-2006Gerwin L, Haupt C, … Kröger S
  • CONCLUSIONS: Acetylcholine receptors are aggregated in the central regions of intrafusal muscle fibres. Single unit muscle spindle afferent responses from isolated mouse extensor digitorum longus muscle were recorded in the absence of fusimotor input to ramp and hold stretches as well as to sinusoidal vibrations in the presence and absence of the acetylcholine receptor blockers d-tubocurarine and α-bungarotoxin. Proprioceptive afferent responses to both types of stretch were enhanced in the presence of either blocker. Blocking acetylcholine uptake and vesicular acetylcholine release by hemicholinium-3 also enhanced stretch-evoked responses. These results represent the first evidence that acetylcholine receptors negatively modulate muscle spindle responses to stretch. The data support the hypothesis that the sensory nerve terminal is able to release vesicles to fine-tune proprioceptive afferent sensitivity.
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