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(tubocurarine chloride)
6,089 results
  • Acute nicotine administration stimulates ciliary activity via α3β4 nAChR in the mouse trachea. [Journal Article]
    Int Immunopharmacol. 2020 Jul; 84:106496.Perniss A, Latz A, … Krasteva-Christ G
  • Mucociliary clearance, the continuous removal of mucus-trapped particles by cilia-driven directed transport of the airway lining fluid, is the primary innate defense mechanism of the airways. It is potently activated by acetylcholine (ACh) addressing muscarinic receptors with a currently less defined role of nicotinic ACh receptors (nAChR). We here set out to determine their contribution in drivi…
  • Endothelium modulates electrical field stimulation-induced contractions of Chelonoidis carbonaria aortic rings. [Journal Article]
    Comp Biochem Physiol C Toxicol Pharmacol. 2020 Jul; 233:108763.Campos R, Jacintho FF, … De Nucci G
  • The role of endothelium in the electrical-field stimulation (EFS)-induced contractions of Chelonoidis carbonaria aorta was investigated. Contractions were evaluated in the presence and absence of L-NAME (100 μM), tetrodotoxin (1 μM), phentolamine (10 and 100 μM), phenoxybenzamine (1 and 10 μM), prazosin (100 μM), idazoxan (100 μM), atropine (10 μM), D-tubocurarine (10 μM) or indomethacin (10 μM).…
  • Discovering Pain in Newborn Infants. [Randomized Controlled Trial]
    Anesthesiology. 2019 08; 131(2):392-395.Anand KJS
  • Randomised Trial of Fentanyl Anesthesia in Preterm Babies Undergoing Surgery: Effects on the Stress Response. By Anand KJ, Sippell WG, and Aynsley-Green A. Lancet 1987; 1:243-8. Reprinted with permission.In a randomised controlled trial, preterm babies undergoing ligation of a patent ductus arteriosus were given nitrous oxide and D-tubocurarine, with (n = 8) or without (n = 8) the addition of fen…
  • StatPearls: Cisatracurium [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Strawbridge Andrew D. AD San Antonio Uniformed Services HEC Sanghavi Devang D Mayo Clinic Hauser Joshua M. JM Brooke Army Medical Center BOOK
  • Cisatracurium besylate is an intermediate-acting, non-depolarizing neuromuscular blocking drug (NMBD). Cisatracurium has a benzylisoquinolinium structure and is the 1R cis-1’R cis isomer of atracurium. Metocurine and d-Tubocurarine are also in the benzylisoquinolinium class.[1] As an NMBD, it has found use as an adjunct to general anesthesia facilitating tracheal intubation and providing skeletal…
  • The Place of Erythroidines in the History of Neuromuscular Blockers. [Historical Article]
    J Anesth Hist. 2019 01; 5(1):22-24.McKenzie AG
  • Between 1938 and 1951 erythroidine derivatives were seriously considered as alternatives to curare for the provision of muscle relaxation. This has been overlooked in the published history of anaesthesia. The first publication on the paralysing effect of an extract of Erythrina americana was in 1877, but this was in a Mexican journal, which was not widely read. Sixty years later erythroidine was …
  • StatPearls: Pancuronium [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Das Gyan N. GN San Antonio Military Medical Center Maani Christopher V. CV US Army BOOK
  • Pancuronium bromide is a long-acting, bis-quaternary aminosteroid, non-depolarizing, neuromuscular blocking drug (NMBD), which was first synthesized in 1964 and found to possess fewer adverse effects with regards to hemodynamic stability and histamine release as compared to the prototypical NMBD, d-tubocurarine.[1][2] After the arrival of intermediate-acting NMBDs such as vecuronium, rocuronium, …
  • Efficacy of antidotes and their combinations in the treatment of acute carbamate poisoning in rats. [Journal Article]
    Toxicology. 2018 09 01; 408:113-124.Stojiljković MP, Škrbić R, … Vulović M
  • CONCLUSIONS: Mechanism of physostigmine-induced lethal effect is predominantly central and it involves inhibition of brain AChE, while pyridostigmine produces the same effect exclusively outside the central nervous system, by inhibiting AChE in the respiratory muscles. As a consequence, increasing doses of atropine and their combination with hexamethonium assure excellent protection against physostigmine toxicity, while the best protection against pyridostigmine is provided by a strictly peripherally acting antinicotinic d-tubocurarine and bispyridinium oxime HI-6. The oxime acts as antidote against physostigmine and pyridostigmine poisoning by reactivating AChE in the brain and diaphragm, respectively.
  • StatPearls: Nondepolarizing Paralytics [BOOK]
    . StatPearls Publishing: Treasure Island (FL) D'Souza Ryan S. RS Mayo Clinic Johnson Rebecca L. RL Mayo Clinic College of Medicine BOOK
  • The introduction of muscle relaxants has revolutionized the practice of anesthesia. By the end of the 1950s, non-depolarizing, neuromuscular, blocking drugs (NMBDs), d-tubocurarine and gallamine, were available.[1] Although these two relaxants are no longer in use, several newer NMBDs have emerged over the last 20 years with safer side effect profiles.[2]
  • Existence of nicotinic receptors in a subset of type I vestibular hair cells of guinea pigs. [Journal Article]
    Brain Res. 2018 02 15; 1681:85-90.Guo CK
  • In mammals, vestibular hair cells (VHCs) are classified as type I and II according to morphological criteria. Acetylcholine (ACh) is identified as the primary efferent neurotransmitter. To date, cholinergic activities have been reported in mammalian type II VHCs, but similar activities in type I VHCs have not been pursued presumably because the body of type I VHCs were suggested to be totally sur…
  • A Model for Link Pruning to Establish Correctly Polarized and Oriented Tip Links in Hair Bundles. [Journal Article]
    Biophys J. 2017 Oct 17; 113(8):1868-1881.Tompkins N, Spinelli KJ, … Barr-Gillespie PG
  • Tip links are thought to gate the mechanically sensitive transduction channels of hair cells, but how they form during development and regeneration remains mysterious. In particular, it is unclear how tip links are strung between stereocilia so that they are oriented parallel to a single axis; why their polarity is uniform despite their constituent molecules' intrinsic asymmetry; and why only a s…
  • A 3D-printed platform for modular neuromuscular motor units. [Journal Article]
    Microsyst Nanoeng. 2017; 3:17015.Cvetkovic C, Rich MH, … Bashir R
  • A complex and functional living cellular system requires the interaction of one or more cell types to perform specific tasks, such as sensing, processing, or force production. Modular and flexible platforms for fabrication of such multi-cellular modules and their characterization have been lacking. Here, we present a modular cellular system, made up of multi-layered tissue rings containing integr…
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