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28 results
  • Prion Protein PRNP: A New Player in Innate Immunity? The Aβ Connection. [Journal Article]
    J Alzheimers Dis Rep 2017; 1(1):263-275Lathe R, Darlix JL
  • The prion protein PRNP has been centrally implicated in the transmissible spongiform encephalopathies (TSEs), but its normal physiological role remains obscure. We highlight emerging evidence that PRNP displays antimicrobial activity, inhibiting the replication of multiple viruses, and also interacts directly with Alzheimer's disease (AD) amyloid-β (Aβ) peptide whose own antimicrobial role is now…
  • Slow internal protein dynamics in solution. [Review]
    J Phys Condens Matter 2014; 26(50):503103Biehl R, Richter D
  • Large-scale domain dynamics in proteins are found when flexible linkers or hinges connect domains. The related conformational changes are often related to the function of the protein,for example by arranging the active center after substrate binding or allowing transport and release of products. The adaptation of a specific active structure is referred to as ‘induced fit’ and is challenged by mod…
  • The unique case of the Niemann-Pick type C cholesterol storage disorder. [Review]
    Pediatr Endocrinol Rev 2014; 12 Suppl 1:166-75Klein AD, Alvarez A, Zanlungo S
  • Niemann-Pick type C disease (NPC) is a neurovisceral lysosomal cholesterol storage disorder that arises from loss-of-f unction mutations in either the NPCI or NPC2 genes. Both genes code for proteins involved in lysosomal cholesterol efflux. NPC is often diagnosed in early childhood, with patients typically displaying cerebellar ataxia, difficulties in Unfortunately, to date, there is no curative…
  • MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways. [Journal Article]
    Biochim Biophys Acta 2013; 1832(1):1-10Ge Y, Pan S, … Yin JQ
  • Recent studies have identified important roles for microRNAs (miRNAs) in many cardiac pathophysiological processes, including the regulation of cardiomyocyte hypertrophy. However, the role of miR-350 in the cardiac setting is still unclear. The objective of this study is to determine whether miR-350 alone can induce pathological cardiac hypertrophy by repressing the SAPK pathway in cardiomyocytes…
  • Caryodendron orinocense ('nuez de Barinas') oil: tocopherol content and use in cosmetics. [Journal Article]
    Int J Cosmet Sci 2000; 22(5):335-40Alfaro Mde J, Padilla FC, Pérez MN
  • Preliminary studies showed the possibility of using the oil extracted from the 'nuez de Barinas' (Caryodendron orinocense Karst.) (also known as 'taque nut'), in cosmetic formulation, due to its UV absorbance spectrum as well as other physical, chemical and toxicological characteristics. Some Amerindians have used this oil as unction. The tree, also called in Venezuela 'nueza' or 'nogal de Barqui…
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