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367,197 results
  • An overview of recent progress in siderophore-antibiotic conjugates. [Journal Article]
    Eur J Med Chem 2019; 182:111615Kong H, Cheng W, … Zhang X
  • Multi-drug resistant infections caused by Gram-negative bacteria have become one of the most important reasons for the failure of clinical anti-infective treatment. Siderophore-antibiotic conjugates, which were designed based on a "Trojan horse" strategy wherein features enabled active uptake to bypass the Gram-negative cell wall, have been expected to be a weapon for anti-infective treatment in …
  • An introduction to effectiveness-implementation hybrid designs. [Journal Article]
    Psychiatry Res 2019; 280:112513Landes SJ, McBain SA, Curran GM
  • The traditional research pipeline that encourages a staged approach to moving an intervention from efficacy trials to the real world can take a long time. To address this issue, hybrid effectiveness-implementation designs were codified to promote examination of both effectiveness and implementation outcomes within a study. There are three types of hybrid designs and they vary based on their prima…
  • Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. [Journal Article]
    Cell Rep 2019; 28(8):1949-1960.e6Costa R, Peruzzo R, … Leanza L
  • Wnt signaling affects fundamental development pathways and, if aberrantly activated, promotes the development of cancers. Wnt signaling is modulated by different factors, but whether the mitochondrial energetic state affects Wnt signaling is unknown. Here, we show that sublethal concentrations of different compounds that decrease mitochondrial ATP production specifically downregulate Wnt/β-cateni…
  • Mechanisms of DNA Uptake by Naturally Competent Bacteria. [Journal Article]
    Annu Rev Genet 2019Dubnau D, Blokesch M
  • Transformation is a widespread mechanism of horizontal gene transfer in bacteria. DNA uptake to the periplasmic compartment requires a DNA-uptake pilus and the DNA-binding protein ComEA. In the gram-negative bacteria, DNA is first pulled toward the outer membrane by retraction of the pilus and then taken up by binding to periplasmic ComEA, acting as a Brownian ratchet to prevent backward diffusio…
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