- The Norm Bourke Box: A Patient-Led Initiative to Improve Care for Rural Patients Requiring Peritoneal Dialysis. [Journal Article]
- PDPerit Dial Int 2019 Jul-Aug; 39(4):390-391
- Patients living in rural communities face many barriers and challenges in accessing peritoneal dialysis (PD) because it often requires travelling long distances, and accommodation away from home for …
Patients living in rural communities face many barriers and challenges in accessing peritoneal dialysis (PD) because it often requires travelling long distances, and accommodation away from home for training and follow-up. Patient perception is that there is a lack of financial support for out-of-pocket expenses, which makes home-based treatments less appealing. It can be difficult for patients to source equipment required to do PD safely and effectively at home, and more difficult for those who live in rural or remote settings. This article describes a patient-led initiative-the "Norm Bourke Box" (NBB) for patients requiring PD in rural New South Wales, Australia. The NBB provides necessary equipment including bathroom scales and a blood pressure machine, that are not supplied by the health service. For patients, this has enabled a "good start" to PD and has helped to alleviate the financial burden and stress of needing to source the equipment required for PD. This also gave patients and staff reassurance because patients could undertake training with the equipment that they would be using at home to support efficient and safe practice at home. Efforts are now underway to expand the distribution of the NBB to help improve access and care for rural patients on PD.
- Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury. [Journal Article]
- AAntioxidants (Basel) 2019 Jun 14; 8(6)
- Induced and frequently unwanted alterations in the mitochondrial structure and functions are a key component of the pathological cascade in many kidney pathologies, including those associated with ac…
Induced and frequently unwanted alterations in the mitochondrial structure and functions are a key component of the pathological cascade in many kidney pathologies, including those associated with acute damage. One of the principal pathogenic elements causing mitochondrial dysfunction in Acute Kidney Injury (AKI) is oxidative stress. After ischemia and nephrotoxic action of drugs, sepsis and systemic inflammation are the most frequent causes of AKI. As the kidney suffers from oxidative stress during sepsis, one of the most promising approaches to alleviate such damaging consequences is the use of antioxidants. Considering administration of lipopolysaccharide (LPS) as a model of sepsis, we demonstrate that the mitochondria of neonatal renal tissue are severely affected by LPS-induced AKI, with pathological ultrastructural changes observed in both the mitochondria of the renal tubular epithelium and the vascular endothelium. Upon mitochondrial damage, we evaluated the effect of the mitochondria-targeted antioxidant plastoquinol decylrhodamine 19 (SkQR1) on the development of acute renal failure in newborn rats associated with systemic inflammation induced by the administration of LPS. We found that SkQR1 administration 3 h before LPS led to decreased urinal expression of the AKI marker neutrophil gelatinase-associated lipocalin 2 (NGAL), in addition to a decrease in urea and creatinine levels in the blood. Additionally, an observed impairment of proliferative activity in the neonatal kidney caused by LPS treatment was also prevented by the treatment of rat pups with SkQR1. Thus, one of the key events for renal tissue damage in neonatal sepsis is an alteration in the structure and function of the mitochondria and the mitochondria-targeted antioxidant SkQR1 is an effective nephroprotective agent, which protects the neonatal kidney from sepsis-induced AKI.
- [Efficacy of electroacupuncture combined with penetrating moxibustion for postpartum stress urinary incontinence]. [Journal Article]
- ZZZhongguo Zhen Jiu 2019 Jun 12; 39(6):599-603
- CONCLUSIONS: EA combined with penetrating moxibustion could improve the urinary control ability, relieve the symptoms of urinary incontinence and have a better long-term effect in patients with postpartum SUI, which is superior to biological feedback training of pelvic floor muscle.
- Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway. [Journal Article]
- OMOxid Med Cell Longev 2019; 2019:7850863
- Cordyceps militaris may show good promise in protecting against chronic kidney disease (CKD) but the molecular mechanism remains unclear. CKD risk is associated with the Toll-like receptor 4/nuclear …
Cordyceps militaris may show good promise in protecting against chronic kidney disease (CKD) but the molecular mechanism remains unclear. CKD risk is associated with the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway. Cordycepin is the main component of Cordyceps militaris and may affect the TLR4/NF-κB pathway. Cordycepin was prepared by preparative HPLC. CKD patients were assigned into Cordyceps militaris (COG, 100 mg daily) and placebo (CG) groups. Cordycepin activity was measured using human embryo kidney cells (HEK293T). Biochemical indices, the levels of TLR4, NF-κB, cyclooxygenase-2 (COX2), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β), were measured by real-time qRT-PCR, or ELISA kits and or Western blot. After 3-month treatment, cordycepin reduced the levels of urinal protein, blood urea nitrogen (BUN), and creatinine by 36.7%±8.6%, 12.5%±3.2%, and 18.3%±6.6%, respectively (P < 0.05). Cordyceps militaris improved lipid profile and redox capacity of CKD patients by reducing the serum levels of TG, TC, and LDL-C by 12.8%±3.6%, 15.7%±4.1%, and 16.5%±4.4% and increasing the HDL-C level by 10.1%±1.4% in the COG group when compared with the CG group, respectively (P < 0.05). The serum levels of cystatin-C (Cys-C), myeloperoxidase (MPO), and malondialdehyde (MDA) were reduced by 14.0%±3.8%, 26.9%±12.3%, and 19.7%±7.9% while nitric oxide (NO) and superoxide dismutase (SOD) were increased by 12.5%±2.9% and 25.3%±13.4% in the COG group when compared with the CG group, respectively (P < 0.05). Cordycepin reduced the levels of TLR4, NF-κB, COX2, TNF-α, and IL-1β in HEK293T cells too (P < 0.05). However, cordycepin could not affect the levels anymore if TLR4 was silenced. Cordyceps militaris protected against CKD progression by affecting the TLR4/NF-κB lipid and redox signaling pathway via cordycepin.
- Deimplementing Untested Practices in Homecare Services: A Preobservational-Postobservational Design. [Journal Article]
- OTOccup Ther Int 2019; 2019:5638939
- CONCLUSIONS: The knowledge transfer and exchange process led to the development of a scientifically sound clinical tool (Algo) and challenged the status quo in clinical settings regarding the use of nonevidence-based practices. However, the deimplementation of in-use practices has not yet been observed. This study highlights the need to act proactively on the deimplementation and implementation processes.
- Exploring the complex relationship between women's sanitation practices and household diarrhea in the slums of Nairobi: a cross-sectional study. [Journal Article]
- BIBMC Infect Dis 2019 Mar 11; 19(1):242
- CONCLUSIONS: Findings suggest that health targets to reduce the prevalence of diarrheal diseases in informal settlements may not be met unless particular attention is paid to the needs of women living in these environments.
- Real-Time Monitoring and Control of Urea Hydrolysis in Cyber-Enabled Nonwater Urinal System. [Journal Article]
- ESEnviron Sci Technol 2019 Mar 19; 53(6):3187-3197
- This research used a cyber-physical system (CPS) to monitor and control the extent of urea hydrolysis in nonwater urinals. Real-time pH and conductivity data were used to control urea hydrolysis inhi…
This research used a cyber-physical system (CPS) to monitor and control the extent of urea hydrolysis in nonwater urinals. Real-time pH and conductivity data were used to control urea hydrolysis inhibition under realistic restroom conditions with acetic acid addition. Variable urination frequencies and urination volumes were used to compare three conditions that affect the progression of urea hydrolysis. Mechanistic and conceptual models were created to evaluate the factors that influence the progression of urea hydrolysis in nonwater urinals. It was found that low urination volumes at low frequencies created ideal conditions for urea hydrolysis to progress. Alternatively, high urination volumes at high frequencies created pseudo-inhibitory conditions because it did not allow for sufficient reaction time or mixing with older urine in the urinal trap. The CPS was used to control urea hydrolysis inhibition by two logics: (1) reactively responding to a pH threshold and (2) predictively responding to past measurements using four lasso regression models. Results from the control logic experiments showed that acid was added once per hour under low use conditions and once in a 4 h experiment for high use conditions. The CPS allowed for full control of urine chemistry in the nonwater urinal, reducing the conditions (i.e., clogging and malodor) that have led to the removal of nonwater urinals in the United States.
- What really happens in the home: a comparison of parent-reported and observed tooth brushing behaviors for young children. [Journal Article]
- BOBMC Oral Health 2019 Feb 21; 19(1):35
- CONCLUSIONS: Observation and video-recording of brushing routines and equipment are feasible and acceptable to families. Observed behaviors are more accurate than self-report for most components of brushing and serve to highlight some of the knowledge issues facing parents, such as the role of fluoride.
- Integrating traditional Chinese medicine healthcare into dementia care plan by reducing the need for special nursing care and medical expenses. [Journal Article]
- MMedicine (Baltimore) 2019; 98(7):e14468
- Reducing the need for advanced nursing care and medical expenses is an essential concern of dementia care. We investigated the impact of traditional Chinese medicine (TCM) on advanced nursing care an…
Reducing the need for advanced nursing care and medical expenses is an essential concern of dementia care. We investigated the impact of traditional Chinese medicine (TCM) on advanced nursing care and medical costs.We used Longitudinal Health Insurance Database to implement a cohort study of patients with dementia between 1997 and 2012 in Taiwan. Data from the onset of dementia to 1st advanced nursing care for the endotracheal tube, urinal indwelling catheterization, and nasogastric tube were assessed using Cox regression proportional hazards model, and independent t test was used to determine the difference of hospitalization costs and days. We also used ANOVA test to compare the hospital cost, hospital stay, and numbers according to different duration of TCM.We assessed 9438 new diagnosed patients with dementia without advanced nursing care were categorized into 2 groups: 4094 (43.4%) TCM users, and 5344 (56.6%) non-TCM users. In the TCM groups, 894 (21.8%) patients were declared as advanced nursing care, while 1683 (31.5%) patients were in non-TCM group. Cox proportional hazard regression indicated that using TCM may decrease the need for advanced nursing care (adjusted hazard ratio (aHR) = 0.61, 95% confidence interval [95% CI]: 0.56-0.66) compared to non-TCM. The TCM users have lower hospitalization costs and hospitalization time compared to non-TCM users.Integrating TCM healthcare into dementia care was found to be associated with a lower need for advanced nursing care, hospitalization costs, and admission time with more benefits from longer durations of TCM use.
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- Novel Interfacial Bulk Heterojunction Technique for Enhanced Response in ZnO Nanogenerator. [Journal Article]
- AAACS Appl Mater Interfaces 2019 Feb 13; 11(6):6078-6088
- In this paper, a direct sustainable approach for the development of a n-ZnO:p-CuO heterojunction (ZCH) through a simple grinding is reported to be an effective technique to enhance the piezoelectric …
In this paper, a direct sustainable approach for the development of a n-ZnO:p-CuO heterojunction (ZCH) through a simple grinding is reported to be an effective technique to enhance the piezoelectric performance of ZCH/polydimethylsiloxane (PDMS) nanocomposite-based nanogenerators (ZP-PNGs). We have first optimized the best concentration for ZnO/PDMS nanocomposite for the realization of the piezoelectric nanogenerator. Later, with the same configuration, we implemented a novel, simple, facile, frugal, and inexpensive technique to fabricate ZCH. The heterojunction results in the improved charge transfer characteristics, low capacitance, and charge nullification contributing to the enhanced piezoelectric output. This reflects in the improvement of the peak-to-peak piezoelectric potential of the device from 2.7 to 9 V. The instantaneous max power density was found to be 0.2 mW/m2. The device can work as a force sensor with improved sensitivity of 1.7 V/N compared to 1.05 V/N of the intrinsic device. The device is being systematically studied for load matching and capacitor charging to demonstrate its practicability. Furthermore, we tested our device to harness the biomechanical energy from day-to-day life activities. Finally, the device was used to fabricate sustainable piezoelectric-based smart urinal systems for low-income group countries.