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Unbound Medicine.
(uvula of cerebellum)
4,137 results
  • Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis. [Journal Article]
    Epilepsy Behav. 2020 Jun 26; 111:107180.Marcián V, Mareček R, … Brázdil M
  • CONCLUSIONS: There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLE-HS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus.
  • Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development. [Journal Article]
    Front Neurosci. 2020; 14:644.Iacomino M, Baldassari S, … Salpietro V
  • Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans. The encoded Wwox protein is a WW domain-containing oxidoreductase that participates in crucial biological processes including tumor suppression, cell growth/differentiation and regulation of st…
  • Drum training induces  long-term plasticity in the cerebellum and connected cortical thickness. [Journal Article]
    Sci Rep. 2020 Jun 22; 10(1):10116.Bruchhage MMK, Amad A, … Williams SCR
  • It is unclear to what extent cerebellar networks show long-term plasticity and accompanied changes in cortical structures. Using drumming as a demanding multimodal motor training, we compared cerebellar lobular volume and white matter microstructure, as well as cortical thickness of 15 healthy non-musicians before and after learning to drum, and 16 age matched novice control participants. After 8…
  • Defining the phenotypical spectrum associated with variants in TUBB2A. [Journal Article]
    J Med Genet. 2020 Jun 22 [Online ahead of print]Brock S, Vanderhasselt T, … Stouffs K
  • CONCLUSIONS: The imaging phenotype associated with pathogenic variants in TUBB2A is highly variable, ranging from a normal cortex to extensive dysgyria with associated brain malformations. For recurrent variants, no clear genotype-phenotype correlations could be established, suggesting the role of additional modifiers.
  • Linking depressive symptom dimensions to cerebellar subregion volumes in later life. [Journal Article]
    Transl Psychiatry. 2020 Jun 19; 10(1):201.Bogoian HR, King TZ, … Dotson VM
  • The present study examined the relationship between subthreshold depressive symptoms and gray matter volume in subregions of the posterior cerebellum. Structural magnetic resonance imaging data from 38 adults aged 51 to 80 years were analyzed along with participants' responses to the Center for Epidemiologic Studies Depression Scale. Subscale scores for depressed mood, somatic symptoms, and lack …
  • Treatment of Primary Autoimmune Cerebellar Ataxia with Mycophenolate. [Journal Article]
    Cerebellum. 2020 Jun 10 [Online ahead of print]Hadjivassiliou M, Grunewald RA, … Hoggard N
  • Immune-mediated ataxias account for a substantial number of sporadic otherwise idiopathic ataxias. Despite some well-characterised entities such as paraneoplastic cerebellar degeneration where diagnostic markers exist, the majority of immune ataxias remained undiagnosed and untreated. We present here our experience in the treatment of suspected primary autoimmune cerebellar ataxia (PACA) using my…
  • StatPearls: Chiari II Malformation [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Kuhn James J Aventura Hospital and Medical Center Emmady Prabhu D. PD UNC school of Medicine, Atrium Health BOOK
  • Chiari II malformation (CM-II), commonly known as Arnold-Chiari malformation, is a relatively common congenital malformation characterized by beaked midbrain, downward displacement of the tonsils, and cerebellar vermis, and spinal myelomeningocele.[1] This malformation is frequently misunderstood as a more severe version of Chiari I malformation (CM-I). However, these are two distinct diseases wi…
  • Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs. [Journal Article]
    Toxicol Pathol. 2020 Jun 01 [Online ahead of print]Pardo ID, Otis D, … Palazzi X
  • Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in …
  • Pontocerebellar Hypoplasia: a Pattern Recognition Approach. [Journal Article]
    Cerebellum. 2020 May 14 [Online ahead of print]Rüsch CT, Bölsterli BK, … Boltshauser E
  • Pontocerebellar hypoplasias (PCH) represent a heterogeneous group of very rare disorders with reduced volume of pons and cerebellum. The term is purely descriptive and does not imply a genetic progressive disease. Currently (as of Jan 01, 2020), 13 different types are listed in OMIM (Online Mendelian Inheritance in Man), associated with 19 different genes. However, a large group of similar imagin…
  • Diagnosis of rhomboencephalosynapsis by MRI in a 5-year-old child. [Case Reports]
    Radiol Case Rep. 2020 Jul; 15(7):867-870.Gómez NT, Mancilla WP, … Leal JCA
  • Rhombencephalosynapsis is a rare defect in the development of the cerebellum, characterized by partial or total agenesis of the vermis, with fusion of the cerebellar hemispheres in the midline. It is usually related to Gómez-López-Hernández Syndrome (cerebellar-trigeminal dermal dysplasia) and VACTERL association association (vertebral defects, vascular anomalies, anal atresia, cardiac anomalies,…
  • [CANVAS: case report on a novel repeat expansion disorder with late-onset ataxia]. [Journal Article]
    Nervenarzt. 2020 Jun; 91(6):537-540.Meindl T, Cordts I, … Deschauer M
  • This article presents the case of a 74-year-old female patient who first developed a progressive disease with sensory neuropathy, cerebellar ataxia and bilateral vestibulopathy at the age of 60 years. The family history was unremarkable. Magnetic resonance imaging (MRI) showed atrophy of the cerebellum predominantly in the vermis and atrophy of the spinal cord. The patient was given the syndromic…
  • Cerebellar Purkinje cell activity modulates aggressive behavior. [Journal Article]
    Elife. 2020 Apr 28; 9Jackman SL, Chen CH, … Regehr WG
  • Although the cerebellum is traditionally associated with balance and motor function, it also plays wider roles in affective and cognitive behaviors. Evidence suggests that the cerebellar vermis may regulate aggressive behavior, though the cerebellar circuits and patterns of activity that influence aggression remain unclear. We used optogenetic methods to bidirectionally modulate the activity of s…
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