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59 results
  • Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases. [Review]
    Neurosci Bull 2019; 35(1):156-166Liu L, Zhao M, … Zang W
  • Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases. Currently, pharmacological interventions primarily aim to inhibit over-excitation of sympathetic nerves, while vagal modulation has been largely neglected. Many studies have demonstrated that increa…
  • Why Whip the Starving Horse When There Are Oats for the Starving Myocardium? [Journal Article]
    Am J Ther 2016 Sep-Oct; 23(5):e1182-7Fürstenwerth H
  • Digoxin is the oldest drug for treatment of heart failure still in clinical use. Despite over 200 years of clinical experience with this drug, the optimal serum concentration required for both efficacy and safety remains unknown. It has been suggested that low doses have more favorable effects than higher ones. Cardiac glycosides act on the Na/K-ATPase (NKA). They show an inverted U-shaped dose-r…
  • Vagomimetic effects of fingolimod: physiology and clinical implications. [Review]
    CNS Neurosci Ther 2014; 20(6):496-502Vanoli E, Pentimalli F, Botto G
  • Fingolimod is a sphingosine 1-phosphate (S1P) receptor modulator approved to treat relapsing-remitting multiple sclerosis (MS). Initiation of treatment with fingolimod has been found to produce transient bradycardia and/or slowing of atrioventricular impulse conduction in a small proportion of patients. This effect is thought to be due to the interaction of fingolimod with S1P receptors on the su…
  • Neuroimmune perspectives in sepsis. [Comment]
    Crit Care 2009; 13(2):133Ulloa L, Deitch EA
  • Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune system and to prevent infectious and inflammatory disorders. Central-acting alpha2-agonists attenuate systemic inflammation and improve survival in experimental sepsis. This anti-inflammatory and therapeutic mechanism of central sympatholytics appears to be mediated by an unexpected vagomimetic potential of t…
  • [New opioids for general anaesthesia and in- and out-hospital analgesia]. [Review]
    Anestezjol Intens Ter 2008 Jan-Mar; 40(1):39-43Dabrowska-Wójciak I, Piotrowski A
  • Over the last 30 years, three new opioids of the piperidine family have been introduced to anaesthesia clinical practice: sufentanil, alfentanil and remifentanil. Alfentanil is a derivative of fentanyl, with quicker onset than that of fentanyl and with shorter duration and more intense vagomimetic properties than those of fentanyl and sufentanil. It may cause less intense respiratory depression t…
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