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3 results
  • Historical and current perspective on tobacco use and nicotine addiction. [Historical Article]
    Trends Neurosci 2011; 34(7):383-92Dani JA, Balfour DJ
  • Although the addictive influence of tobacco was recognized very early, the modern concepts of nicotine addiction have relied on knowledge of cholinergic neurotransmission and nicotinic acetylcholine receptors (nAChRs). The discovery of the 'receptive substance' by Langley, that would turn out to be nAChRs, and 'Vagusstoff' (acetylcholine) by Loewi, coincided with an exciting time when the concept…
  • Acetylcholine--from Vagusstoff to cerebral neurotransmitter. [Historical Article]
    J Hist Neurosci 2009; 18(1):47-58Sourkes TL
  • This paper is concerned with some of the events in physiology that followed Otto Loewi's description of a substance that he named "Vagusstoff"; events that led eventually to the establishment of acetylcholine as a transmitter substance in the nervous system. Much of the work achieving this recognition of acetylcholine as a neurotransmitter took place in the middle third of the twentieth century; …
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