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186,446 results
  • Induction of aortic valve calcification by celecoxib and its COX-2 independent derivatives is glucocorticoid-dependent. [Journal Article]
    Cardiovasc Pathol 2019; 46:107194Vaidya KA, Donnelly MP, … Butcher JT
  • CONCLUSIONS: Here we identify glucocorticoids as a possible source of the increased valvular calcification risk associated with celecoxib and its cyclooxygenase-2 independent derivatives. In the absence of glucocorticoids, these inhibitors effectively reduce calcification. Furthermore, the offtarget effects are not due to the drug's intrinsic properties as dual cyclooxygenase-2 and cadherin-11 inhibitors. These findings inform future design and development of celecoxib derivatives for potential clinical therapy.
  • Transcatheter closure of left ventricular pseudoaneurysm after mitral valve replacement. [Case Reports]
    Ann Thorac Surg 2020Arnaz A, Akansel S, … Sarioglu T
  • Left ventricular pseudoaneurysm (LVPA) is a rare but lethal complication of mitral valve replacement (MVR) or myocardial infarction. Early correction is necessary for patients with extensive and expanding LVPA. We report a transcatheter closure of LVPA after MVR. A 63-year-old woman presented with an LVPA two months after MVR. The repeated computed tomographic scan and transthoracic echocardiogra…
  • Acute coronary artery obstruction following surgical repair of congenital heart disease. [Journal Article]
    J Thorac Cardiovasc Surg 2019Goldsmith MP, Allan CK, … Porras D
  • CONCLUSIONS: Time from clinically relevant postoperative sentinel event to diagnosis of coronary artery obstruction by angiography was associated with transplant-listing-free survival. Clinicians should maintain a high index of suspicion for coronary obstruction and consider early catheterization and coronary angiography for patients in whom post-operative coronary compromise is suspected.
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