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356,073 results
  • Nimodipine pharmacokinetics after intraventricular injection of sustained-release nimodipine for subarachnoid hemorrhage. [Journal Article]
    J Neurosurg 2019; :1-7Macdonald RL, Hänggi D, … NEWTON Investigators
  • CONCLUSIONS: Plasma concentrations of nimodipine similar to those achieved with oral nimodipine and lasting for 21 days could be achieved after a single intraventricular injection of EG-1962. The CSF concentrations from EG-1962, however, were at least 2 orders of magnitude higher than those with oral nimodipine. These results supported a phase 3 study that demonstrated a favorable safety profile for EG-1962 but yielded inconclusive efficacy results due to notable differences in clinical outcome based on baseline disease severity.Clinical trial registration no.: NCT01893190 (ClinicalTrials.gov).
  • B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy. [Journal Article]
    Am J Transplant 2019Moore C, Gao B, … Zorn E
  • Cardiac allograft vasculopathy (CAV) is associated with intragraft B cell infiltrates. Here, we studied the clonal composition of B cell infiltrates using 4 graft specimens with CAV. Using deep sequencing, we analyzed the immunoglobulin heavy chain variable region repertoire in both graft and blood. Results showed robust B cell clonal expansion in the graft but not in the blood for all cases. Sev…
  • β-Amyloid Peptide: the Cell Compartment Multi-faceted Interaction in Alzheimer's Disease. [Review]
    Neurotox Res 2019Picone P, Nuzzo D, … Di Carlo M
  • Alzheimer's disease (AD) is the most widespread form of dementia, characterized by memory loss and reduction of cognitive functions that strongly interfere with normal daily life. Numerous evidences show that aggregates of the amyloid beta peptide, formed by 39 to 42 amino acid residues (Aβ39-43), from soluble small oligomers to large fibrils are characteristic markers of this pathology. However,…
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