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(vascular stiffening)
1,813 results
  • Vascular mineralocorticoid receptor activation and disease. [Review]
    Exp Eye Res 2019; 188:107796Barrera-Chimal J, Jaisser F
  • Mineralocorticoid receptor activation in endothelial and smooth muscle cells can promote vascular disease by increasing oxidative stress, promoting inflammation, accelerating vascular stiffness, remodeling, and calcification, altering vessel responsiveness to various vasoactive factors, thus altering vascular tone and blood pressure, and by altering angiogenesis. Here, we review the recent eviden…
  • The Role of Vascular Aging in Atherosclerotic Plaque Development and Vulnerability. [Journal Article]
    Curr Pharm Des 2019Liberale L, Camici GG
  • The ongoing demographical shift is leading to an unprecedented aging of the population. As a consequence, the prevalence of age-related diseases such as atherosclerosis and its thrombotic complications is set to increase in the near future. Endothelial dysfunction and vascular stiffening characterize arterial aging and set the stage for the development of cardiovascular diseases. Atherosclerotic …
  • Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review. [Review]
    J Am Coll Cardiol 2019; 74(9):1237-1263Chirinos JA, Segers P, … Townsend R
  • A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and protects the microvasculature from potentially harmful fluctuations in pressure and blood flow. Large-artery (aortic) stiffening, which occurs with aging and various pathologic states, impairs this cushioning function, and has important consequences on cardiovascular health, including isolated systolic hy…
  • Mechanical characterisation of human ascending aorta dissection. [Journal Article]
    J Biomech 2019; 94:138-146Deplano V, Boufi M, … Alimi YS
  • Mechanical characteristics of both the healthy ascending aorta and acute type A aortic dissection were investigated using in vitro biaxial tensile tests, in vivo measurements via transoesophageal echocardiography and histological characterisations. This combination of analysis at tissular, structural and microstructural levels highlighted the following: (i) a linear mechanical response for the di…
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