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Unbound Medicine.
(veno occlusive disease)
3,588 results
  • Imaging in Hepatic Veno-occlusive Disease/Sinusoidal Obstruction Syndrome. [Review]
    Biol Blood Marrow Transplant. 2020 Jun 25 [Online ahead of print]Chan SS, Colecchia A, … Bourhis JH
  • Veno-occlusive disease/sinusoidal obstruction syndrome is a potentially life-threatening complication of hematopoietic cell transplantation. Early diagnosis and, subsequently, earlier intervention have been shown to be beneficial to clinical outcomes. Diagnostic criteria from the European Society for Blood and Marrow Transplantation include recommendations on the use of imaging for diagnosis. Thi…
  • A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype. [Case Reports]
    Pulm Circ. 2020 Jul-Sep; 10(3):2045894020931315.Oriaku I, LeSieur MN, … Frost A
  • Mutations in the gene encoding bone morphogenetic protein receptor type II (BMPR2) have been associated with heritable pulmonary arterial hypertension (HPAH), whereas mutations in the gene encoding eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) are associated with heritable pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis (HPVOD/PCH). We describe two unrel…
  • Pulmonary capillary haemangiomatosis: a distinct entity? [Journal Article]
    Eur Respir Rev. 2020 Jun 30; 29(156)Weatherald J, Dorfmüller P, … Montani D
  • Pulmonary capillary haemangiomatosis (PCH) is a rare and incompletely understood histopathological finding characterised by abnormal capillary proliferation within the alveolar interstitium, which has long been noted to share many overlapping features with pulmonary veno-occlusive disease (PVOD). But are PCH and PVOD distinct entities that occur in isolation, or are they closely intertwined manif…
  • Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study. [Journal Article]
    Arch Toxicol. 2020 May; 94(5):1739-1751.Ebmeyer J, Rasinger JD, … Hessel-Pras S
  • Pyrrolizidine alkaloids (PA) are secondary plant metabolites that occur as food and feed contaminants. Acute and subacute PA poisoning can lead to severe liver damage in humans and animals, comprising liver pain, hepatomegaly and the development of ascites due to occlusion of the hepatic sinusoids (veno-occlusive disease). Chronic exposure to low levels of PA can induce liver cirrhosis and liver …
  • Unique Mutation in SP110 Resulting in Hepatic Veno-Occlusive Disease with Immunodeficiency. [Case Reports]
    Case Rep Pediatr. 2020; 2020:3460631.Hamdoun O, Al Mulla A, … Al-Shibli A
  • Familial hepatic veno-occlusive disease with immunodeficiency (VODI, OMIM: 235550) is a rare form of combined immune deficiency (CID) that presents in the first few months of life with failure to thrive, recurrent infections, opportunistic infections along with liver impairment. Herein, we are describing a Pakistani patient with a homozygous novel variant in the SP110 gene, presenting with classi…
  • The Speckled Protein (SP) Family: Immunity's Chromatin Readers. [Review]
    Trends Immunol. 2020 May 05 [Online ahead of print]Fraschilla I, Jeffrey KL
  • Chromatin 'readers' are central interpreters of the epigenome that facilitate cell-specific transcriptional programs and are therapeutic targets in cancer and inflammation. The Speckled Protein (SP) family of chromatin 'readers' in humans consists of SP100, SP110, SP140, and SP140L. SPs possess functional domains (SAND, PHD, bromodomain) that dock to DNA or post-translationally modified histones …
  • Diagnosis and Treatment of VOD/SOS After Allogeneic Hematopoietic Stem Cell Transplantation. [Review]
    Front Immunol. 2020; 11:489.Bonifazi F, Barbato F, … Colecchia A
  • Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is a rare complication characterized by hepatomegaly, right-upper quadrant pain, jaundice, and ascites, occurring after high-dose chemotherapy, hematopoietic stem cell transplantation (HSCT) and, less commonly, other conditions. We review pathogenesis, clinical appearance and diagnostic criteria, risk factors, prophylax…
  • Molecular Profiling of Vascular Remodeling in Chronic Pulmonary Disease. [Journal Article]
    Am J Pathol. 2020 Apr 07 [Online ahead of print]Neubert L, Borchert P, … Jonigk D
  • Pulmonary hypertension and pulmonary vascular remodeling (PVR) are common in many lung diseases leading to right ventricular dysfunction and death. Differences in PVR result in significant prognostic divergences in both the pulmonary arterial and venous compartments, as in pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD), respectively. Our goal was to identify com…
  • Pulmonary vein occlusion and veno-occlusive disease in a bilateral lung transplant patient: A case report. [Case Reports]
    Respir Med Case Rep. 2020; 30:101031.Wang X, Zheng K, … Allen T
  • A pulmonary vein occlusion and biopsy proven pulmonary veno-occlusive disease (PVOD) and hemangiomatosis is found in a bilateral lung transplant patient. A 61-year-old male presents with dyspnea and chest pain with minimal exertion at routine follow up on post-transplant day of 50. Chest CT demonstrates new occlusion of bilateral superior pulmonary veins and diffuse pulmonary edema. Pulmonary vei…
  • Sinusoidal obstruction syndrome. [Practice Guideline]
    Clin Res Hepatol Gastroenterol. 2020 Apr 03 [Online ahead of print]de Lédinghen V, Villate A, … Plessier A
  • Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is characterized by concentric and non-thrombotic obstruction of the sinusoid and central vein lumen with no identified primitive or thrombotic hepatic vein lesions. The initial lesion is a result of endothelial denudation, corresponding to the migration of damaged sinusoidal cells to the central veins of the hepat…
  • Idiopathic refractory ascites after allogeneic stem cell transplantation: a previously unrecognized entity. [Journal Article]
    Blood Adv. 2020 Apr 14; 4(7):1296-1306.Varma A, Abraham SC, … Popat UR
  • At our center, we observed a series of patients who developed transudative refractory ascites secondary to noncirrhotic, non-veno-occlusive disease (VOD)-related portal hypertension after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients were considered to have idiopathic portal hypertension-related refractory ascites (IRA) if they developed ascites secondary to intrahepati…
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