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318,854 results
  • A Case Series of Five People Living with HIV Hospitalized with COVID-19 in Chicago, Illinois. [Journal Article]
    AIDS Patient Care STDS. 2020 May 29 [Online ahead of print]Ridgway JP, Farley B, … McNulty M
  • The risk of COVID-19 among people living with HIV (PLWH) is largely unknown and there have been very few reported cases in the literature. We report a case series of five PLWH with COVID-19. We identified all patients with a diagnosis of HIV who tested positive for SARS-CoV-2 at University of Chicago Medicine between March 1, 2020, and April 7, 2020. We retrospectively collected data regarding de…
  • Perceived indoor air quality and psychosocial work environment in office, school and health care environments in Finland. [Journal Article]
    Int J Occup Med Environ Health. 2020 May 27 [Online ahead of print]Tähtinen K, Remes J, … Reijula K
  • CONCLUSIONS: Compared to earlier findings, the most often perceived IE-related symptoms and complaints have increased in Finnish health care environments. The office employees' perceptions of psychosocial work environment remained fairly unchanged whereas health care personnel more often assessed their psychosocial environment as positive compared to previous reports. Instead of exact reference values, comparing the results of <i>IA Questionnaires</i> with the distributions and mean values of the results of this study may be more informative for those striving to solve IE-related problems. The presented distribution and mean values of perceived symptoms, environmental complaints and psychosocial work environment might help to relate the results to other workplaces. This, in turn, might increase the understanding that <i>IA Questionnaire</i> results are influenced by many factors. The results presented can be used as new reference material when interpreting the results of <i>IA Questionnaires</i> in office, school and health care environments.
  • Management of community-acquired pneumonia: essential tips for the physician on call. [Journal Article]
    Br J Hosp Med (Lond). 2020 May 02; 81(5):1-9.Avari M, Brown JS
  • Community-acquired pneumonia is a common clinical problem requiring admission to hospital, with a particularly high incidence in the elderly population and those with significant comorbidities. Diagnosis is made on the combination of a short history of respiratory symptoms and systemic ill-health with new examination and/or radiological features of consolidation. Multiple other infective and non-…
  • Respiratory Control by Phox2b-expressing Neurons in a Locus Coeruleus-preBötzinger Complex Circuit. [Journal Article]
    Neurosci Bull. 2020 May 28 [Online ahead of print]Liu N, Fu C, … Wang S
  • The locus coeruleus (LC) has been implicated in the control of breathing. Congenital central hypoventilation syndrome results from mutation of the paired-like homeobox 2b (Phox2b) gene that is expressed in LC neurons. The present study was designed to address whether stimulation of Phox2b-expressing LC (Phox2bLC) neurons affects breathing and to reveal the putative circuit mechanism. A Cre-depend…
  • Postintubation Dysphagia During COVID-19 Outbreak-Contemporary Review. [Journal Article]
    Dysphagia. 2020 May 28 [Online ahead of print]Frajkova Z, Tedla M, … Geneid A
  • The COVID-19 is a global pandemic. Its rapid dissemination and serious course require a novel approach to healthcare practices. Severe disease progression is often associated with the development of the Acute Respiratory Distress Syndrome and may require some form of respiratory support, including endotracheal intubation, mechanical ventilation, and enteral nutrition through a nasogastric tube. T…
  • Presentation and Outcomes of Patients with ESKD and COVID-19. [Journal Article]
    J Am Soc Nephrol. 2020 May 28 [Online ahead of print]Valeri AM, Robbins-Juarez SY, … Husain SA
  • CONCLUSIONS: The association of COVID-19 with high mortality in patients with ESKD on dialysis reinforces the need to take appropriate infection control measures to prevent COVID-19 spread in this vulnerable population.
  • Gastroschisis in the neonatal period: A prospective case-series in a Brazilian referral center. [Journal Article]
    J Pediatr Surg. 2020 Apr 29 [Online ahead of print]Martins BMR, Abreu I, … Moreira MEL
  • CONCLUSIONS: This study provides a comprehensive picture of gastroschisis during the neonatal period in a Brazilian referral center, emphasizing the significantly higher risk for morbidity and mortality among complex patients than among simple patients and the few advantages of the sutureless technique over the sutured technique in terms of closing the defect.
  • End-of-life care in a pediatric intensive care unit: the impact of the development of a palliative care unit. [Journal Article]
    BMC Palliat Care. 2020 May 28; 19(1):74.Bobillo-Perez S, Segura S, … Cambra FJ
  • CONCLUSIONS: The main cause of life-support limitation was the unfavourable evolution of the underlying pathology. Families were involved in the decision-making process in a high percentage of the cases. The development of the Palliative Care Unit changed life-support limitation in our unit, with differences detected in the type of patient and in the strategy used. Increased confidence among intensivists when providing end-of-life care, and the availability of a Palliative Care Unit may contribute to improvements in the quality of end-of-life care.
  • Hereditary Ataxia: A Focus on Heme Metabolism and Fe-S Cluster Biogenesis. [Review]
    Int J Mol Sci. 2020 May 26; 21(11)Chiabrando D, Bertino F, Tolosano E
  • Heme and Fe-S clusters regulate a plethora of essential biological processes ranging from cellular respiration and cell metabolism to the maintenance of genome integrity. Mutations in genes involved in heme metabolism and Fe-S cluster biogenesis cause different forms of ataxia, like posterior column ataxia and retinitis pigmentosa (PCARP), Friedreich's ataxia (FRDA) and X-linked sideroblastic ane…
  • Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal Tumor. [Journal Article]
    Cells. 2020 May 26; 9(6)Huang WK, Gao J, … Lui WO
  • Metabolic reprogramming is a hallmark of cancer cells in response to targeted therapy. Decreased glycolytic activity with enhanced mitochondrial respiration secondary to imatinib has been shown in imatinib-sensitive gastrointestional stromal tumors (GIST). However, the role of energy metabolism in imatinib-resistant GIST remains poorly characterized. Here, we investigated the effect of imatinib t…
  • Animal Models of Metabolic Epilepsy and Epilepsy Associated Metabolic Dysfunction: A Systematic Review. [Review]
    Pharmaceuticals (Basel). 2020 May 26; 13(6)Kundap UP, Paudel YN, Shaikh MF
  • Epilepsy is a serious neurological disorder affecting around 70 million people globally and is characterized by spontaneous recurrent seizures. Recent evidence indicates that dysfunction in metabolic processes can lead to the alteration of neuronal and network excitability, thereby contributing to epileptogenesis. Developing a suitable animal model that can recapitulate all the clinical phenotype…
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