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(ventilator dependent)
2,158 results
  • Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury. [Journal Article]
    Crit Care Med 2019; 47(11):e911-e918González-López A, López-Alonso I, … Spies CD
  • Mechanical ventilation can cause ventilator-induced brain injury via afferent vagal signaling and hippocampal neurotransmitter imbalances. The triggering mechanisms for vagal signaling during mechanical ventilation are unknown. The objective of this study was to assess whether pulmonary transient receptor potential vanilloid type-4 (TRPV4) mechanoreceptors and vagal afferent purinergic receptors …
  • Refractory Central Neurogenic Hyperventilation: A Novel Approach Utilizing Mechanical Dead Space. [Case Reports]
    Front Neurol 2019; 10:937Sweidan AJ, Bower MM, … Groysman LI
  • This report describes the successful management of a case of central neurogenic hyperventilation (CNH) refractory to high dose sedation by increasing the mechanical dead space. A 46-year-old male presented with a history of multiple neurological symptoms. Following an extensive evaluation, he was diagnosed with primary diffuse CNS lymphoma and started on high dose steroids. After initial symptoma…
  • StatPearls: Pressure Support Ventilation [BOOK]
    StatPearls Publishing: Treasure Island (FL) Abramovitz Aaron A Sparrow Hospital Sung Sharon S Sparrow Hospital BOOK
  • Pressure support ventilation (PSV) is a mode of positive pressure mechanical ventilation in which the patient triggers every breath. PSV is deliverable with invasive (through an endotracheal tube) or non-invasive (via full face or nasal mask) mechanical ventilation. This ventilatory mode is the most comfortable for patients and is a useful ventilator setting for weaning from invasive ventilation …
  • Impact of intensive care unit supportive care on the physiology of Ebola virus disease in a universally lethal non-human primate model. [Journal Article]
    Intensive Care Med Exp 2019; 7(1):54Poliquin G, Funk D, … Strong JE
  • CONCLUSIONS: The model employed for this study is reflective of an intramuscular infection in humans (e.g., needle stick) and is highly lethal to NHPs. Using this model, we found that the animals developed progressive severe organ dysfunction and profound shock preceding death. While the overall impact of supportive care on the observed pathophysiology was limited, we did observe some time-dependent positive responses. Since this model is highly lethal, it does not reflect the full spectrum of human EVD. Our findings support the need for continued development of animal models that replicate the spectrum of human disease as well as ongoing development of anti-Ebola therapies to complement supportive care.
  • Whole-body exposure to cigarette smoke alters oocyte miRNAs expression in C57BL/6 mice. [Journal Article]
    Mol Reprod Dev 2019Budani MC, D'Aurora M, … Tiboni GM
  • Cigarette smoke is toxic for the female reproductive system with particular reference to the ovary. The purpose of the study was to investigate if the microRNAs (miRNAs) pattern could be altered by cigarette smoke exposure in mouse oocytes. For this purpose, C57BL/6 mice were whole-body exposed to three cigarettes daily, 7 days/week, for 2 or 4 months by a specific rodent ventilator. Mice were th…
  • Survival analysis and decannulation outcomes of infants with tracheotomies. [Journal Article]
    Laryngoscope 2019Salley J, Kou YF, … Johnson RF
  • CONCLUSIONS: This study demonstrated that the time to decannulation and likelihood of decannulation varies based on the indication for the tracheostomy. The majority of patients with a tracheostomy were not decannulated at the conclusion of this study. Median time to decannulation was 2.5 years for patients with a median death time of 6 months.
  • Evaluation of studies on extended versus standard infusion of beta-lactam antibiotics. [Journal Article]
    Am J Health Syst Pharm 2019; 76(18):1383-1394Chen M, Buurma V, … Fahim G
  • CONCLUSIONS: Gram-negative infections are a serious concern among hospitalized patients and require innovative pharmacokinetic dosing strategies to achieve clinical success, especially as the emergence of resistant gram-negative pathogens has outpaced the development of new antibiotics. Beta-lactam antibiotics exhibit time-dependent activity, which means that optimal efficacy is achieved when free drug concentrations stay above the minimum inhibitory concentration for an extended duration of the recommended dosage interval. EI piperacillin-tazobactam therapy has demonstrated improved clinical outcomes and decrease mortality in critically ill patients with gram-negative infections, particularly Pseudomonas aeruginosa infections. EI meropenem has shown higher therapeutic success rates for patients with febrile neutropenia and shorter intensive care unit (ICU) length of stay (LOS) with a reduction in ventilator days in patients with multidrug-resistant ventilator-associated pneumonia. However, a larger study showed no difference in clinical outcomes between standard-infusion and EI meropenem. EI cefepime has been associated with decreased mortality and shorter ICU LOS in patients with Pseudomonas aeruginosa infections. Common challenges associated with EI beta-lactam antibiotics include Y-site incompatibilities, lack of intravenous access, and tubing residuals. It is important to note that factors such as diverse patient populations and study methodology, along with various antibiotic dose regimens, may have contributed to conflicting data on EI beta-lactam therapy.Based on most published literature, there appears to be a favorable trend toward use of EI beta-lactam therapy in clinical practice, particularly in critically ill patients with gram-negative infections.
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