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29,114 results
  • Specificity of cobamide remodeling, uptake, and utilization in Vibrio cholerae. [Journal Article]
    Mol Microbiol 2019Ma AT, Tyrell B, Beld J
  • Cobamides are a group of compounds including vitamin B12 that can vary at the lower base position of the nucleotide loop. They are synthesized de novo by only a subset of prokaryotes, but some organisms encode partial biosynthesis pathways for converting one variant to another (remodeling) or completing biosynthesis from an intermediate (corrinoid salvaging). Here we explore the cobamide specific…
  • Insights Into Nitric Oxide Modulated Quorum Sensing Pathways. [Review]
    Front Microbiol 2019; 10:2174Heckler I, Boon EM
  • The emerging threat of drug resistant bacteria has prompted the investigation into bacterial signaling pathways responsible for pathogenesis. One such mechanism by which bacteria regulate their physiology during infection of a host is through a process known as quorum sensing (QS). Bacteria use QS to regulate community-wide gene expression in response to changes in population density. In order to…
  • Non O1 Vibrio cholerae as a cause of bacteremic lower limb cellulitis: A case report. [Journal Article]
    Int J Surg Case Rep 2019; 64:62-65Abdelhafiz TA, Alnimr AM, … Hakami AM
  • CONCLUSIONS: Upon review of literature, we only found few cases have been reported of cellulitis due to V. cholerae. A degree of hepatic impairment or immunocompromised state like Diabetes Mellitus, chronic infections, malignancies, and peripheral vascular disease are seen in the majority of non-gastrointestinal V. cholerae infections which suggests that it should be included in the differential diagnosis of bacteremic skin and soft tissue infections in patients with underlying illnesses.Cholerae should be included in the differential diagnosis of any bacteremic skin and soft tissue infections especially in elderly, comorbid and immune-compromised patients. Well-timed, proper antibiotic and surgical treatments are important in management of the infection to decrease morbidity and mortality.
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